human longevity protein

Introduction

Proteins associated with exceptional longevity in humans Protein list derived from SNP data. Obviously, other proteins play a role in human longevity, if for no other reason than the association of protein defect(s) with disease.

More general terms

• protein

More specific terms

• 2-oxoglutarate dehydrogenase, mitochondrial; 2-oxoglutarate dehydrogenase complex component E1; OGDC-E1; alpha-ketoglutarate dehydrogenase (OGDH)
• 5'-nucleotidase domain-containing protein 1 (NT5DC1, NT5C2L1, LP2642)
• acetylglucosaminyltransferase-like protein LARGE; acetylglucosaminyltransferase-like 1A (LARGE, LARGE1, KIAA0609)
• acrosome formation-associated factor; equatorin (AFAF, EQTN, C9orf11)
• ADAMTS-like protein 1; ADAMTSL-1; Punctin-1 (ADAMTSL1, ADAMTSR1, C9orf94, UNQ528/PRO1071)
• alcohol dehydrogenase class-3; alcohol dehydrogenase-3; alcohol dehydrogenase-5; alcohol dehydrogenase class chi chain; S-(hydroxymethyl)glutathione dehydrogenase; glutathione-dependent formaldehyde dehydrogenase; FDH (ADH5, ADHX, ADH3)
• allograft inflammatory factor 1; AIF-1; ionized Ca+2-binding adapter molecule 1; protein G1 (AIF1, G1, IBA1)
• amiloride-sensitive cation channel 1, neuronal; amiloride-sensitive brain Na+ channel; amiloride-sensitive cation channel neuronal 1; acid-sensing ion channel 2; ASIC2; brain Na+ channel 1; BNaC1; BNC1; mammalian degenerin homolog (ACCN1, ACCN, BNAC1 M...
• aminopeptidase O; AP-O (AOPEP, C9orf3, ONPEP)
• amyloid beta A4 protein-binding family B member 2; protein Fe65-like 1 (APBB2, FE65L, FE65L1)
• Angel homolog 1 (ANGEL1, KIAA0759)
• angiopoietin-1 receptor; tyrosine-protein kinase receptor TIE-2; hTIE2; tyrosine-protein kinase receptor TEK; tunica interna endothelial cell kinase; p140 TEK; CD202b (TEK, TIE2)
• band 4.1-like protein 4B; FERM-containing protein CG1; protein EHM2 (EPB41L4B, EHM2)
• basic fibroblast growth factor receptor 1; FGFR-1; bFGF-R; Fms-like tyrosine kinase 2; c-fgr; CD331 (FGFR1, FGFBR, FLG, FLT2)
• beta-defensin 1; BD-1; hBD-1; defensin, beta 1 (DEFB1, BD1, HBD1)
• BRCA1-A complex subunit BRE; BRCA1/BRCA2-containing complex subunit 45; brain & reproductive organ-expressed protein (BRE, BRCC45)
• BTB/POZ domain-containing protein KCTD1; K+ channel tetramerization domain-containing protein 1 (KCTD1, C18orf5)
• butyrophilin-like protein 2; BTL-II (BTNL2)
• calmodulin-binding transcription activator 1 (CAMTA1, KIAA0833, MSTP023)
• carbohydrate sulfotransferase 11; chondroitin 4-O-sulfotransferase 1; chondroitin 4-sulfotransferase 1; C4S-1; C4ST-1; C4ST1 (CHST11)
• carcinoembryonic antigen-related cell adhesion molecule 16; carcinoembryonic antigen-like 2 (CEACAM16, CEAL2)
• caspase recruitment domain-containing protein 14; CARD-containing MAGUK protein 2; carma 2 (CARD14, CARMA2)
• catenin alpha-2; alpha-catenin-related protein; alpha N-catenin (CTNNA2, CAPR)
• catenin alpha-3; alpha T-catenin; cadherin-associated protein (CTNNA3)
• catenin delta-2; delta-catenin; neural plakophilin-related ARM-repeat protein; NPRAP; neurojungin; GT24 (CTNND2, NPRAP)
• CD153; tumor necrosis factor ligand superfamily member 8; CD30 ligand; CD30-L (TNFSF8, CD30L, CD30LG)
• CD49a; integrin alpha-1; CD49 antigen-like family member A; laminin & collagen receptor; VLA-1 (ITGA1)
• CD95; Fas antigen; tumor necrosis factor receptor superfamily member 6; apo-1 antigen; apoptosis-mediating surface antigen FAS; FASLG receptor (FAS, APT1, FAS1, TNFRSF6)
• cell adhesion molecule 1; immunoglobulin superfamily member 4; nectin-like protein 2; NECL-2; tumor suppressor in lung cancer 1; TSLC-1; synaptic cell adhesion molecule; spermatogenic immunoglobulin superfamily; SgIGSF (CADM1, IGSF4, NECL2, SYNCAM, TSLC1)
• cingulin-like protein 1; junction-associated coiled-coil protein; paracingulin (CGNL1, JACOP, KIAA1749)
• citrate lyase beta subunit-like protein, mitochondrial; citrate lyase beta-like; beta-methylmalate synthase (CLYBL, CLB)
• complement C2; contains: complement C2b fragment; complement C2a fragment (C2)
• CUB & SUSHI domain-containing protein 3; CUB & SUSHI multiple domains protein 3 (CSMD3, KIAA1894)
• cyclin-dependent kinase 4 inhibitor B; p14-INK4b; p15-INK4b; p15INK4B; multiple tumor suppressor 2; MTS-2 (CDKN2B, MTS2)
• cyclin-dependent kinase-14 (CDK14); cell division protein kinase 14; serine/threonine protein kinase PFTAIRE-1; hPFTAIRE1 (CDK14, KIAA0834, PFTK1)
• cyclin-dependent kinase-6 (CDK6, PLSTIRE)
• cytochrome p450 5A; thromboxane A [TxA] synthase 1 (TBXAS1, CYP5, CYP5A1)
• cytosolic beta-glucosidase; cytosolic beta-glucosidase-like protein 1 (GBA3, CBG, CBGL1)
• dedicator of cytokinesis protein 8 (DOCK8)
• dedicator of cytokinesis protein2 (DOCK2, KIAA0209)
• desmoglein-1; cadherin family member 4; desmosomal glycoprotein 1; DG1; DGI; Pemphigus foliaceus antigen (DSG1, CDHF4)
• discs large homolog 7; disks large-associated protein 5; DAP-5; disks large-associated protein DLG7; hepatoma up-regulated protein; HURP (DLGAP5, DLG7, KIAA0008)
• DNA repair protein RAD51 homolog 2; R51H2; RAD51-like protein 1; Rad51B (RAD51L1, RAD51B, REC2)
• DNA repair protein RAD51 homolog 4; R51H3; RAD51-like protein 3; TRAD (RAD51L3, RAD51D)
• dopamine D4 receptor; dopamine D2C receptor (DRD4)
• E3 ubiquitin-protein ligase DZIP3; DAZ-interacting protein 3; RNA-binding ubiquitin ligase of 138 kDa; hRUL138 (DZIP3, KIAA0675)
• E3 ubiquitin-protein ligase parkin; EC=6.3.2.-; parkinson juvenile disease protein 2; parkinson disease protein 2 (PARK2 PRKN)
• Ecto-NOX disulfide-thiol exchanger 1; constitutive ecto-NOX; cNOX; candidate growth-related & time keeping constitutive hydroquinone [NADH] oxidase; cCNOX; cell proliferation-inducing gene 38 protein; [Includes: hydroquinone [NADH] oxidase; protein dis...
• endoplasmic reticulum-Golgi intermediate compartment protein 1 (ER-Golgi intermediate compartment 32 kD protein, ERGIC-32, ERGIC1, ERGIC32, KIAA1181, HT034)
• estrogen-related receptor gamma; estrogen receptor-related protein 3; ERR gamma-2; nuclear receptor subfamily 3 group B member 3 (ESRRG, ERR3, ERRG2, KIAA0832, NR3B3)
• eukaryotic translation initiation factor 4E type 3; eIF-4E type 3; eIF-4E3; eIF4E type 3; eIF4E-3 (EIF4E3)
• F-box-like/WD repeat-containing protein TBL1XR1; nuclear receptor corepressor/HDAC3 complex subunit TBLR1; TBL1-related protein 1; transducin beta-like 1X-related protein 1 (TBL1XR1, IRA1, TBLR1)
• fragile histidine triad protein; AP3A hydrolase; bis(5'-adenosyl)-triphosphatase; diadenosine 5',5'''-P1,P3-triphosphate hydrolase (FHIT)
• G-protein coupled receptor 27; super conserved receptor expressed in brain 1 (GPR27, SREB1)
• gastric inhibitory polypeptide; glucose-dependent insulinotropic polypeptide (GIP)
• GATA binding factor-4; transcription factor GATA-4 (GATA4)
• GDH/6PGL endoplasmic bifunctional protein; endoplasmic bifunctional protein precursor [Includes: glucose 1-dehydrogenase, hexose-6-phosphate dehydrogenase, 6-phosphogluconolactonase] (6PGL, H6PD, G1DH)
• glucocorticoid receptor; GR; nuclear receptor subfamily 3 group C member 1 (NR3C1, GRL)
• glypican-6 (GPC6)
• heparan sulfate glucosamine 3-O-sulfotransferase 3B1; heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3B1; 3-OST-3B; heparan sulfate 3-O-sulfotransferase 3B1; h3-OST-3B (HS3ST3B1, 3OST3B1, HS3ST3B)
• homeobox protein MOX-2; growth arrest-specific homeobox protein GAX; mesenchyme homeobox 2; MEOX2; GAX (MOX2)
• interleukin-12 subunit alpha; IL-12A; cytotoxic lymphocyte maturation factor 35 kD subunit; CLMF p35; IL-12 subunit p35; NK cell stimulatory factor chain 1; NKSF1 (IL12A, NKSF1)
• killer cell lectin-like receptor subfamily F member 1; lectin-like receptor F1; activating coreceptor NKp80; C-type lectin domain family 5 member C (KLRF1, CLEC5C, ML)
• kinesin family member 13B; kinesin-like protein GAKIN, guanylate kinase-associated kinesin, kinesin-like protein KIF13B (KIF13B)
• klotho precursor (KL)
• lamin-A/C; 70 kD lamin; renal carcinoma antigen NY-REN-32 (LMNA, LMN1)
• large proline-rich protein BAT2; HLA-B-associated transcript 2; protein G2 (BAT2, PRRC2A, G2)
• leucine-rich repeat & immunoglobulin-like domain-containing nogo receptor-interacting protein 2; leucine-rich repeat neuronal protein 3; leucine-rich repeat neuronal protein 6C (LINGO2, LERN3, LRRN6C, UNQ9234/PRO31993)
• LIM/homeodomain protein LHX1B; LIM homeobox transcription factor 1 beta; LIM/homeobox protein 1.2; LMX-1.2 (LMX1B)
• low-density lipoprotein receptor-related protein 1B; LRP-1B; low-density lipoprotein receptor-related protein-deleted in tumor; LRP-DIT (LRP1B, LRPDIT)
• lymphocyte antigen 6 complex locus protein G6d; protein Ly6-D; megakaryocyte-enhanced gene transcript 1 protein (LY6G6D, C6orf23, G6D, MEGT1, NG25)
• lymphocyte antigen 6 complex locus protein G6e (LY6G6E)
• lymphocyte antigen 6 complex locus protein G6f (LY6G6F, C6orf21, G6F, NG32)
• lymphocyte antigen 86; Ly-86; protein MD-1 (LY86, MD1)
• lysosomal-trafficking regulator; Beige homolog (LYST, CHS, CHS1)
• macrophage colony-stimulating factor 1 receptor; CSF-1 receptor; CSF-1-R; CSF-1R; M-CSF-R; proto-oncogene c-Fms; CD115 (CSF1R, FMS)
• membrane-associated phosphatidylinositol transfer protein 3; phosphatidylinositol transfer protein, membrane-associated 3; PITPnm 3; Pyk2 N-terminal domain-interacting receptor 1; NIR-1 (PITPNM3 NIR1)
• methionine aminopeptidase 1; MAP 1; MetAP 1; peptidase M 1 (METAP1, KIAA0094)
• mitochondrial import receptor subunit TOM40 homolog; protein Haymaker; translocase of outer membrane 40 kD subunit homolog; p38.5 (TOMM40, C19orf1, PEREC1, TOM40)
• MKL/myocardin-like protein 1; megakaryoblastic leukemia 1 protein; megakaryocytic acute leukemia protein; myocardin-related transcription factor A; MRTF-A (MKL1, KIAA1438, MAL)
• Mn+2 superoxide dismutase (SOD-2, Mn-SOD, SOD2)
• myelin transcription factor 1-like protein; MyT1-L; MyT1L (MYT1L, KIAA1106)
• myosin-9b; unconventional myosin-9b (MYO9B, MYR5)
• N-sulphoglucosamine sulphohydrolase; sulfoglucosamine sulfamidase; heparan sulfamidase; heparan-N-sulfatase (SGSH, HSS)
• Na+-independent sulfate anion transporter; solute carrier family 26 member 11 (SLC26A11)
• NADH dehydrogenase B14.7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11; complex I-B14.7; CI-B14.7; NADH-ubiquinone oxidoreductase subunit B14.7 (NDUFA11)
• nesprin-1; enaptin; myocyte nuclear envelope protein 1; Myne-1; nuclear envelope spectrin repeat protein 1; synaptic nuclear envelope protein 1; syne-1 (SYNE1, C6orf98, KIAA0796, KIAA1262, KIAA1756 MYNE1)
• neuron navigator 2; helicase APC down-regulated 1; retinoic acid inducible in neuroblastoma 1; steerin-2; unc53H2 (NAV2, HELAD1, KIAA1419, RAINB1, STEERIN2)
• NF-kappa B p50 subunit; NF-kappa B p105 subunit; NF-kappa C; DNA-binding factor KBF1; EBP-1 (NFKB1)
• NF-kappaB inhibitor epsilon; NF-kappa-BIE; I-kappa-B-epsilon; IkappaBepsilon; IkB-epsilon; IkB-E (NFKBIE, IKBE)
• olfactory receptor 56A1; olfactory receptor OR11-75 (OR56A1)
• p16ink4A; cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3; cyclin-dependent kinase 4 inhibitor A; CDK4I; p16-INK4a; p16INK4A; p16-INK4; multiple tumor suppressor 1; MTS-1; p16MTS1 (CDKN2A, CDKN2, MTS1)
• PAP-associated domain-containing protein 5; topoisomerase-related function protein 4-2; TRF4-2 (PAPD5)
• Pecanex-like protein 2 (PCNX2, PCNXL2, KIAA0435)
• phosphatase-2A 55 kD regulatory subunit B beta; PP2A subunit B-B-beta isoform; PP2A; subunit B-B55-beta isoform; PP2A subunit B-PR55-beta isoform; PP2A subunit B-R2-beta isoform (PPP2R2B)
• phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein; P-Rex1; Ptdins(3,4,5)-dependent Rac exchanger 1 (PREX1, KIAA1415)
• phytanoyl-CoA hydroxylase-interacting protein; phytanoyl-CoA hydroxylase-associated protein 1; PAHX-AP1; PAHXAP1 (PHYHIP, DYRK1AP3, KIAA0273)
• pleckstrin homology domain-containing family A member 7; PH domain-containing family A member 7 (PLEKHA7)
• prominin-1; antigen AC133; prominin-like protein 1; CD133 (PROM1, PROML1, MSTP061)
• properdin factor B; complement factor B; C3/C5 convertase; glycine-rich beta glycoprotein (GBC); PBF2 (CFB)
• protein BAT5; abhydrolase domain-containing protein 16A; HLA-B-associated transcript 5; protein G5; protein ABHD16A (ABHD16A, BAT5, G5, NG26, PP199)
• protein BTG3; BTG family member 3; protein Tob5; abundant in neuroepithelium area protein (BTG3, ANA, TOB5)
• protein KIAA1377 (KIAA1377)
• protein neurobeachin; lysosomal-trafficking regulator 2; protein; BCL8 (NBEA, BCL8B, KIAA1544, LYST2)
• pyroglutamyl-peptidase 1; pyrrolidone-carboxylate peptidase; 5-oxoprolyl-peptidase; PGP-I (PGPEP1, PGPI)
• RING finger protein 145 (RNF145, FLJ31951)
• RNA polymerase II elongation factor ELL2 (ELL2)
• Ryanodine receptor 3; RYR-3; RyR3; brain-type ryanodine receptor; brain ryanodine receptor-Ca+2 release channel (RYR3, HBRR)
• sarcospan; K-ras oncogene-associated protein; Kirsten-ras-associated protein (SSPN, KRAG)
• scavenger mRNA-decapping enzyme DcpS; m7GpppX diphosphatase; DCS-1; Hint-related 7meGMP-directed hydrolase; histidine triad protein member 5; HINT-5 (DCPS, DCS1, HINT5, HSPC015)
• SCP2 sterol-binding domain-containing protein 1; protein C20orf79 (SCP2D1, C20orf79)
• semaphorin-6A; semaphorin VIA; sema VIA; semaphorin-6A-1; SEMA6A-1 (SEMA6A, KIAA1368, SEMAQ)
• serine/threonine protein kinase PLK3; cytokine-inducible serine/threonine protein kinase; FGF-inducible kinase; polo-like kinase 3; PLK-3; proliferation-related kinase (PLK3, CNK, FNK, PRK)
• SH2 domain-containing protein 4A; protein SH(2)A; protein phosphatase 1 regulatory subunit 38 (SH2D4A, PPP1R38, SH2A)
• solute carrier family 25 member 21; mitochondrial 2-oxodicarboxylate carrier (SLC25A21, ODC)
• solute carrier family 4 member 4; electrogenic sodium bicarbonate cotransporter 1; sodium bicarbonate cotransporter; Na+/HCO3- cotransporter (SLC4A4, kNBC1, NBC, NBC1, NBCE1)
• solute carrier family 6 member 7; Na+-dependent proline transporter (SLC6A7, PROT)
• sulfatase-modifying factor 1; C-alpha-formyglycine-generating enzyme 1 (SUMF1, FGE, PSEC0152, UNQ3037/PRO9852)
• suppressor of cytokine signaling 2; SOCS-2; cytokine-inducible SH2 protein 2; CIS-2; STAT-induced STAT inhibitor 2; SSI-2 (SOCS2, CIS2, SSI2, STATI2)
• synaptotagmin-13; synaptotagmin XIII; SytXIII (SYT13, KIAA1427)
• T-complex-associated testis-expressed protein 1 (Tcte-1, TCTE1, MGC33600 )
• Tctex1 domain-containing protein 4; Tctex-2-beta, Protein N22.1 (TCTEX1D4, LOC343521)
• tetratricopeptide repeat protein 27; TPR repeat protein 27 (TTC27)
• tetratricopeptide repeat protein 6; TPR repeat protein 6 (TTC6)
• thymus high mobility group box protein TOX; thymocyte selection-associated high mobility group box protein TOX (TOX, KIAA0808)
• transcription factor COE3; early B-cell factor 3; EBF-3; olf-1/EBF-like 2; O/E-2; OE-2 (EBF3, COE3)
• transmembrane protein 2 (TMEM2, KIAA1412)
• tripartite motif-containing protein 25; zinc finger protein 147; estrogen-responsive finger protein; Efp; RING finger protein 147 (TRIM25, EFP, RNF147, ZNF147)
• tumor necrosis factor receptor superfamily member 11A; receptor activator of NF-KB; osteoclast differentiation factor receptor; ODFR; CD265 (TNFRSF11A, RANK)
• tumor suppressor candidate 3; Mg+2 uptake/transporter TUSC3; protein N33 (TUSC3, N33)
• ubiquitin-conjugating protein-E2H
• vacuolar protein sorting-associated protein 13D (VPS13D, KIAA0453)
• vasohibin-1 (VASH1, KIAA1036, VASH)
• VPS10 domain-containing receptor SorCS1 (SORCS1, SORCS)
• VPS10 domain-containing receptor SorCS2 (SORCS2, KIAA1329)
• WD repeat protein 21B; DDB1- & CUL4-associated factor 4-like protein 1 (WDR21B, LOC285429, DCAF4L1)
• WD repeat protein 72 (WDR72)
• Werner syndrome ATP-dependent helicase (WRN, RECQ3, RECQL2)
• WW domain-containing oxidoreductase; fragile site FRA16D oxidoreductase (WWOX, FOR, WOX1)
• xanthine dehydrogenase (XDH, XDHA)
• XK-related protein 6 (XKR6, C8orf21, C8orf7, XRG6)
• zinc finger protein 288; zinc finger & BTB domain-containing protein 20; dendritic-derived BTB/POZ zinc finger protein (ZBTB20, DPZF, ZNF288)
• ZW10 interactor; ZW10-interacting protein 1; Zwint-1 (ZWINT)

Additional terms

• evolutionary divergent human protein
• shortened longevity protein