amiloride-sensitive cation channel 1, neuronal; amiloride-sensitive brain Na+ channel; amiloride-sensitive cation channel neuronal 1; acid-sensing ion channel 2; ASIC2; brain Na+ channel 1; BNaC1; BNC1; mammalian degenerin homolog (ACCN1, ACCN, BNAC1 MDEG)

Function

• cation channel with high affinity for Na+
• gated by extracellular protons
• inhibited by the diuretic amiloride
• also permeable for Li+ & K+
• generates a biphasic current with a fast inactivating & a slow sustained phase
• heteromeric channel assembly seems to modulate activity
• homotetramer or heterotetramer with other ASIC proteins (probable)
• interacts with STOM (putative)
• interacts with PRKCABP & ACCN3

Structure

• belongs to the amiloride-sensitive Na+ channel family

Compartment

• cell membrane; multi-pass membrane protein
• localized at the plasma membrane of neurons, in the soma & punctated peripheral processes (putative)

Alternative splicing

named isoforms=2

Expression

• brain & spinal cord
• isoform 1 is also detected in testis, liver, colon & ovary

Notes

• inhibited by anti-inflammatory agents including salicylic acid (putative)
• regulated by Zn+2

More general terms

• transmembrane 2 protein
• amiloride-sensitive cation channel
• human longevity protein

Database

• OMIM: https://mirror.omim.org/entry/601784
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=40
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:40
• UniProt: http://www.uniprot.org/uniprot/Q16515.html