amiloride (Midamor, Amipramidin, Modamide)
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Introduction
Tradename: Midamor.
Indications
Dosage
Tabs: 5 mg.
Dosage adjustment in renal failure
Adverse effects
Drug interactions
- hyperkalemia potentiated by concomitant use of ACE inhibitors, NSAIDs, diabetes.
- drug interaction(s) SGLT2 inhibitors (flozins) with diuretics
- drug interaction(s) of diuretics in combination with Zn+2
- drug interaction(s) of antiarrhythmic agents in combination with diuretics
- drug interaction(s) of calcium channel blockers with diuretics
- drug interaction(s) of spironolactone with potassium-sparing diuretics
- drug interaction(s) of ACE inhibitors with potassium-sparing diuretics
- drug interaction(s) of diuretics with angiotensin II receptor antagonists
- drug interaction(s) of diuretics with ACE inhibitors
- drug interaction(s) of NSAIDs, diuretics & angiotensin II receptor antagonists
- drug interaction(s) of NSAIDs, diuretics & ACE inhibitors
- drug interaction(s) of NSAIDs & antihypertensives
Mechanism of action
- inhibits collecting duct lumenal Na+ channel
- blocks uptake of Li+ by the distal tubule & collecting duct
- mild extracellular fluid volume contraction
- increased Na+ & H2O absorption at the proximal tubule
- decreased urine volume
More general terms
Component of
References
- ↑ The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- ↑ Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 625
- ↑ Jump up to: 3.0 3.1 A Pocket Guide to the 2019 Beer's Criteria. American Geriatrics Society.