PRKCA-binding protein; protein interacting with C kinase 1; protein kinase C-alpha-binding protein (PICK1, PRKCABP)

Function

• probable adapter protein
• binds & organizes subcellular localization of membrane proteins containing some PDZ recognition sequence
• role in clustering of receptors, possibly by acting at the receptor internalization level
• may be regulated upon PRKCA activation
• may regulate ACCN3-ACCN2 heteromeric cation channel
• interacts presynaptically with:
  • monoamine transporters SLC6A2 & SLC6A3
  • channel proteins ACCN1 & ACCN2
  • GTP-binding proteins ARF1 & ARF3
• interacts with PRKCA
• interacts with the ephrin receptor tyrosine kinases EPHA7, EPHB1 & EPHB2
• interacts with ERBB2
• interacts with BTG2
• interacts with the glutamate receptors GRIA2, GRIA3
• interacts with GRM4 (isoform A), GRM7 & GRM8
• interacts with NAPA & NAPB; interaction with NAPA & NAPB disrupts the interaction with GRIA2 & its internalization
• interacts with UNC5A
• interacts with CXADR
• interacts through its PDZ domain with the C-terminal tail of PRLHR
• interacts (via AH domain) with NCS1/FREQ (Ca+2-dependent)

Structure

• monomer & homodimer
• contains 1 AH domain
• contains 1 PDZ domain (DHR domain)

Compartment

• cytoplasm, perinuclear region
• cell junction, synapse
• present at excitatory synapses

Expression

ubiquitous

More general terms

• nuclear protein
• phosphoprotein

Additional terms

• protein kinase C-alpha (PKC-III, PRKCA, PKCA PRKACA)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9463
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9463
• OMIM: https://mirror.omim.org/entry/605926
• UniProt: http://www.uniprot.org/uniprot/Q9NRD5.html