guanine nucleotide regulatory protein (GNRP)

Introduction

GNRP are molecular switches that bind GTP & GDP. They slowly hydrolyze GTP to GDP. The balance between GTP-bound (active) & GDP-bound (inactive) states is regulated by opposing action of GTPase-activating proteins (GAP) & that of GDP/GTP dissociation stimulators (GDS).

                  GAP
GNRP ... GTP     ----->   GNRP ... GDP

                  GDS
GNRP ... GDP     ----->   GNRP ... GTP

Notes

• the ras proteins of membrane-associated GNRP

More general terms

• protein
• regulatory molecule

More specific terms

• cdc42 protein
• developmentally-regulated GTP-binding protein 1; DRG-1; neural cell expressed developmentally down-regulated protein 3; NEDD-3 (DRG1, NEDD3)
• developmentally-regulated GTP-binding protein 2; DRG-2 (DRG2)
• elongation factor 1
• elongation factor 1-alpha
• elongation factor Tu GTP-binding domain-containing protein 1 (EFTUD1)
• eukaryotic initiation factor 2
• eukaryotic peptide chain release factor GTP-binding subunit ERF3A; eukaryotic peptide chain release factor subunit 3a; eRF3a; G1 to S phase transition protein 1 homolog; G1/S transition protein 1 homolog; GTP-binding protein GST1-HS (GSPT1, ERF3A)
• eukaryotic release factor
• eukaryotic translation initiation factor 5B (eIF5B, translation initiation factor IF-2, KIAA0741)
• G-protein
• GPN-loop GTPase 1; MBD2-interacting protein; MBDin; XPA-binding protein 1 (GPN1, MBDIN, XAB1, HUSSY-23)
• GTP-binding protein 10 (protein obg homolog 2, ObgH2, GTPBP10, OBGH2, UG0751c10)
• GTP-binding protein 1; G-protein 1; GP-1; GP1 (GTPBP1)
• GTP-binding protein 2 (GTPBP2)
• GTP-binding protein 6; pseudoautosomal GTP-binding protein-like (GTPBP6, PGPL)
• GTP-binding protein 8 (GTPBP8)
• GTP-binding protein 9 (GTPBP9, OLA1)
• GTP-binding protein ARD1; ADP-ribosylation factor domain-containing protein 1; tripartite motif-containing protein 23; RING finger protein 46 (TRIM23, ARD1, ARFD1, RNF46)
• GTP-binding protein era homolog; hERA; ERA-W; conserved ERA-like GTPase; CEGA (ERAL1, HERA)
• GTP-binding protein GEM; GTP-binding mitogen-induced T-cell protein; RAS-like protein KIR (GEM, KIR)
• GTP-binding protein GUF1 homolog (GUF1)
• GTP-binding protein RAD; Ras associated with diabetes; RAD1 (RRAD, RAD)
• GTP-binding protein REM 1; GTPase-regulating endothelial cell sprouting; Rad & Gem-like GTP-binding protein 1 (REM1, GES, REM)
• GTP-binding protein Rheb; Ras homolog enriched in brain; Rheb GTPase (RHEB, RHEB2)
• GTP-binding protein Rhes; Ras homolog enriched in striatum; tumor endothelial marker 2 (RASD2, TEM2)
• GTP-binding protein SAR1a; COPII-associated small GTPase (SAR1A, SAR1, SARA, SARA1)
• GTP-binding protein SAR1b; GTP-binding protein B; GTBPB (SAR1B, SARA2, SARB)
• GTPase, IMAP family
• guanine nucleotide-binding protein-like 1; GTP-binding protein HSR1 (GNL1, HSR1)
• Guanine nucleotide-binding protein-like 3-like protein (GNL3L)
• guanylate-binding protein 3 (GTP-binding protein 3, guanine nucleotide-binding protein 3, GBP-3, GBP3)
• guanylate-binding protein 4 (GTP-binding protein 4, guanine nucleotide-binding protein 4, GBP-4, GBP4)
• guanylate-binding protein 6; GTP-binding protein 6; guanine nucleotide-binding protein 6; GBP-6, (GBP6)
• guanylate-binding protein 7 (GTP-binding protein 7, guanine nucleotide-binding protein 7, GBP-7, guanylate-binding protein 4-like, GBP7, GBP4L)
• HBS1-like protein (ERFS, HBS1L, HBS1, KIAA1038)
• interferon-induced GTP-binding protein Mx1; myxovirus resistance protein 1; interferon-regulated resistance GTP-binding protein MxA; interferon-induced protein p78; IFI-78K (MX1)
• interferon-induced GTP-binding protein Mx2; myxovirus resistance protein 2; interferon-regulated resistance GTP-binding protein MxB; p78-related protein (MX2)
• interferon-induced guanylate-binding protein 1; guanine nucleotide-binding protein 1; GTP-binding protein 1; GBP-1; HuGBP-1 (GBP1)
• interferon-induced guanylate-binding protein 2; guanine nucleotide-binding protein 2; GTP-binding protein 2; GBP-2; HuGBP-2 (GBP2)
• Miro domain-containing protein C1orf89 (C1orf89, RSG1)
• mitochondrial ribosome-associated GTPase 2; GTP-binding protein 5; protein obg homolog 1; ObgH1 (MTG2, GTPBP5, OBGH1)
• mouse DRG protein
• nucleolar GTP-binding protein 1; chronic renal failure gene protein; GTP-binding protein NGB (GTPBP4, CRFG, NOG1)
• nucleolar GTP-binding protein 2; autoantigen NGP-1 (GNL2, NGP1)
• nucleolar GTP-binding protein 3; guanine nucleotide-binding protein-like 3; E2-induced gene 3 protein; novel nucleolar protein 47; NNP47; nucleolar GTP-binding protein 3; nucleostemin (GNL3, E2IG3, NS)
• Rab-like protein 2A (RABL2A)
• ras superfamily protein
• Ras-related GTP-binding protein (RRAG)
• Rho-related BTB domain-containing protein
• Rho-related GTP-binding protein RhoJ (Tc10-like GTP-binding protein TCL, RHOJ, ARHJ, RASL7B, RHOI, TCL)
• Rho-related GTP-binding protein RhoU (Wnt-1 responsive Cdc42 homolog 1, WRCH-1, Ryu GTPase, CDC42-like GTPase 1, Rho GTPase-like protein ARHU, GTP-binding protein-like 1, RHOU, ARHU, CDC42L1, G28K, WRCH1, SB128)
• Rho-related GTP-binding protein RhoV (Wnt-1 responsive Cdc42 homolog 2, WRCH-2, CDC42-like GTPase 2, GTP-binding protein-like 2, Rho GTPase-like protein ARHV, RHOV, ARHV, WRCH2)
• rhotekin (RTKN)
• sec4 protein
• septin
• signal recognition particle 54 kD subunit (SRP54)
• signal recognition particle receptor subunit alpha; SR-alpha; docking protein alpha; DP-alpha (SRPR)
• signal recognition particle receptor subunit beta; SR-beta; protein APMCF1 (SRPRB)

Additional terms

• GTPase-activating protein (GAP)
• guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS)