guanine nucleotide-binding protein-like 1; GTP-binding protein HSR1 (GNL1, HSR1)

Function

• possible regulatory or functional link with the histocompatibility cluster
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• in contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern
• belongs to the MMR1/HSR1 GTP-binding protein family

Alternative splicing

named isoforms=2

More general terms

• guanine nucleotide regulatory protein (GNRP)
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P36915.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2794
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2794
• OMIM: https://mirror.omim.org/entry/143024