DNA damage

Introduction

Damage to DNA in the form of DNA base lesions or apurinic/ apyrimidinic (AP)-sites. These may be repaired by DNA repair mechanisms, or if extensive, the cell may signal the need for apoptosis.

DNA damage may induce activity of sodium-hydrogen exchanger (NHE-1), which leads to a rise in intracellular pH

deamidation of antiapoptic proteins, including bcl-xL may facilitate apoptosis

Assays for different types of DNA damage vary in utility

• comet assay
• unscheduled DNA synthesis

Tandemly repeated BRCT domains are characteristic of proteins involved in DNA damage signaling.

• MDC1

More general terms

• biochemistry

More specific terms

• apurinic/apyrimidinic (AP) site
• Comet assay (comet tail moment)
• DNA base lesion

Additional terms

• DNA repair