bcl-xL
Jump to navigation
Jump to search
Function
- inhibits apoptosis through a bax-independent mechanism
- associates with caspase 9 & APAF-1, inhibiting maturation of caspase 9 mediated by APAF-1[4]
- deamidation of bcl-xL with increased intracellular pH resulting from phosphorylation of NHE1 after DNA damage abrogates antiapoptic activity of bcl-xL[5]
- overexpression leads to increased numbers of mature thymocytes
Pathology
- BCR-ABL fusion gene may inhibit Bcl-xL deamidation in patients with CML[5]
- JAK2 mutation may inhibit Bcl-xL deamidation in patients with polycythemia vera &/or myelofibrosis[5]
Pharmacology
- UBX1325 binds to Bcl-xL & selectively induces apoptosis in senescent cells[6]
- a single dose of UBX1325 improved visula acuity in patients with diabetic macular edema or neovascular age-related macular degeneration[6]
More general terms
References
- ↑ Boise LH et al bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell. 1993 Aug 27;74(4):597-608. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8358789
- ↑ Cheng EH, Levine B, Boise LH, Thompson CB, Hardwick JM. Bax-independent inhibition of apoptosis by Bcl-XL. Nature. 1996 Feb 8;379(6565):554-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8596636
- ↑ Yang XF, Weber GF, Cantor H. A novel Bcl-x isoform connected to the T cell receptor regulates apoptosis in T cells. Immunity. 1997 Nov;7(5):629-39. PMID: https://www.ncbi.nlm.nih.gov/pubmed/9390687
- ↑ 4.0 4.1 Hu Y et al Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation. Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4386-91. PMID: https://www.ncbi.nlm.nih.gov/pubmed/9539746
- ↑ 5.0 5.1 5.2 5.3 Zhao R et al. Inhibition of the Bcl-xL deamidation pathway in myeloproliferative disorders. N Engl J Med 2008 Dec 25; 359:2778. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19109573
- ↑ 6.0 6.1 6.2 Bankhead C 'Senolytic' Therapy Shows Promise in Neovascular Eye Disease. Clearing out dying cells, approach has implications far beyond ophthalmology. MedPage Today July 14, 2022 https://www.medpagetoday.com/meetingcoverage/asrs/99734