p210 bcr/abl

Pathology

• transforming product of Philadelphia chromosome-positive chronic myelogenous leukemia (CML)
• protein product of a chimeric gene of bcr with abl
• increased autophosphorylation occurs

Laboratory

• BCR-ABL1 fusion protein in blood/tissue

Comparative biology

• the protein is transforming in mice.

More general terms

• breakpoint cluster region protein P160 (p160BCR)
• tyrosine-protein kinase ABL1
• oncoprotein

Additional terms

• chromosomal translocation t9q34.1:22q11 (Philadelphia chromosome; bcr/abl)
• chronic myeloid leukemia (CML, granulocytic leukemia)

Database

• UniProt: http://www.uniprot.org/uniprot/P11274.html
• UniProt: http://www.uniprot.org/uniprot/P00519.html
• OMIM: https://mirror.omim.org/entry/151410
• OMIM: https://mirror.omim.org/entry/189980