tyrosine-protein kinase ABL1; Abelson murine leukemia viral oncogene homolog 1; proto-oncogene c-Abl; p150 (ABL1, ABL, JTK7)

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Function

Cofactor: Mg+2 or Mn+2

ATP + protein-L-tyrosine = ADP + protein-L-tyrosine phosphate

Structure

Compartment

Alternative splicing

named isoforms=2, IA. IB

Expression

widely expressed

Pathology

Pharmacology

More general terms

More specific terms

Additional terms

References

  1. Hunter T. Cooperation between oncogenes. Cell. 1991 Jan 25;64(2):249-70. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1988147
  2. Kipreos ET, Wang JY. Differential phosphorylation of c-Abl in cell cycle determined by cdc2 kinase and phosphatase activity. Science. 1990 Apr 13;248(4952):217-20. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2183353
  3. Kipreos ET, Wang JY. Cell cycle-regulated binding of c-Abl tyrosine kinase to DNA. Science. 1992 Apr 17;256(5055):382-5. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1566087
  4. 4.0 4.1 Kemp BE, Pearson RB. Protein kinase recognition sequence motifs. Trends Biochem Sci. 1990 Sep;15(9):342-6. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2238044
  5. 5.0 5.1 Pawson T Protein modules and signalling networks Nature 373:573 1995 (SH2-domain) PMID: https://www.ncbi.nlm.nih.gov/pubmed/7531822
  6. UniProt http://www.uniprot.org/uniprot/P00519.html
  7. Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/ABL.html
  8. CGP resequencing studies http://www.sanger.ac.uk/perl/genetics/CGP/cgp_viewer?action=gene&ln=ABL1
  9. NIEHS-SNPs http://egp.gs.washington.edu/data/abl1/
  10. Wikipedia; Note: Abl entry http://en.wikipedia.org/wiki/Abl_gene

Database