transketolase (TK, TKT)

Function

-..........-

sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate
                   <-->
D-ribose 5-phosphate + D-xylulose 5-phosphate

Cofactor:

• binds 1 Ca+2 per subunit (putative)
• binds 1 thiamine pyrophosphate per subunit

Structure

• homodimer
• belongs to the transketolase family

Pathology

• implicated in Wernicke-Korsakoff syndrome

More general terms

• transketolase family protein
• Ca+2 binding protein
• phosphoprotein

Additional terms

• hexose monophosphate shunt, pentose phosphate pathway or phosphogluconate shunt
• transketolase 2 (transketolase-like 1, transketolase related protein, TKTL1, TKR, TKT2)

Database

• OMIM: https://mirror.omim.org/entry/277730
• OMIM: https://mirror.omim.org/entry/606781
• UniProt: http://www.uniprot.org/uniprot/P29401.html