CDK5 & ABL1 enzyme substrate 1; interactor with CDK3 1; Ik3-1 (CABLES1 CABLES)

Function

• cyclin-dependent kinase binding protein
• enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases
  • phosphorylation of CDK5 by activated ABL1
    • increases CDK5 activity
    • involved in neuronal development
  • phosphorylation of CDK2 by WEE1
    • decreased CDK2 activity
    • growth inhibition
• positively affects neuronal outgrowth
• regulates p53/p73-induced cell death (putative)
• component of several complexes
  • complex with p53
  • complexes with CDK2, CDK3, CDK5, ABL1, TDRD7, PCTK2, CCNA1, CCNE1, TP73
• interacts with CDK2, CDK3, CDK5, ABL1, TDRD7
• phosphorylated on Ser-313 by CCNE1
• phosphorylated on Ser/Thr by CDK5 & on Tyr by ABL1
• phosphorylated in vitro by CCNA1/CDK2, CCNE1/CDK2, CCNA1/CDK3 & CCNE1/CDK3

Structure

belongs to the cyclin family

Compartment

• nucleus, cytoplasm
• located in cell body & proximal region of the developing axonal shaft of immature neurons
• located in axonal growth cone of mature neurons

Alternative splicing

named isoforms=3

Expression

• expressed in breast, pancreas, colon, head & neck (at protein level)
• expression in endometrial epithelium fluctuates during menstrual cycle, greater in secretory phase than proliferative phase
• up-regulated by progesterone
• down-regulated by estrogen

Pathology

• decreased expression in > 90% of endometrial cancers

More general terms

• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=91768
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:91768
• OMIM: https://mirror.omim.org/entry/609194
• UniProt: http://www.uniprot.org/uniprot/Q8TDN4.html