cellular tumor antigen p53; tumor suppressor p53, phosphoprotein p53; antigen NY-CO-13 (TP53, p53)

From Aaushi
Jump to navigation Jump to search

Function

Cofactor: binds 1 Zn+2 per subunit

Structure

Compartment

Alternative splicing

Expression

Pathology

Genetics

Laboratory

Notes

  • see motifs in linr drawing for further description of functional domains

More general terms

More specific terms

Additional terms

References

  1. Wilcock D, Lane DP. Localization of p53, retinoblastoma and host replication proteins at sites of viral replication in herpes-infected cells. Nature. 1991 Jan 31;349(6308):429-31. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1671528
  2. Hunter T. Cooperation between oncogenes. Cell. 1991 Jan 25;64(2):249-70. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1988147
  3. Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery CA Jr, Butel JS, Bradley A. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature. 1992 Mar 19;356(6366):215-21. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1552940
  4. Lane DP. Cancer. p53, guardian of the genome. Nature. 1992 Jul 2;358(6381):15-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1614522
  5. Mack DH, Vartikar J, Pipas JM, Laimins LA. Specific repression of TATA-mediated but not initiator- mediated transcription by wild-type p53. Nature. 1993 May 20;363(6426):281-3. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8387645
  6. Gottlieb TM, Jackson SP. Protein kinases and DNA damage. Trends Biochem Sci. 1994 Nov;19(11):500-3. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7855895
  7. 7.0 7.1 Cross SM, Sanchez CA, Morgan CA, Schimke MK, Ramel S, Idzerda RL, Raskind WH, Reid BJ. A p53-dependent mouse spindle checkpoint. Science. 1995 Mar 3;267(5202):1353-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7871434
  8. 8.0 8.1 Enoch T, Norbury C. Cellular responses to DNA damage: cell-cycle checkpoints, apoptosis and the roles of p53 and ATM. Trends Biochem Sci. 1995 Oct;20(10):426-30. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8533157
  9. 9.0 9.1 Cordon-Cardo C. Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia. Am J Pathol. 1995 Sep;147(3):545-60. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7677168
  10. Levine AJ. p53, the cellular gatekeeper for growth and division. Cell. 1997 Feb 7;88(3):323-31. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/9039259
  11. Lee S, Elenbaas B, Levine A, Griffith J. p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches. Cell. 1995 Jun 30;81(7):1013-20. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7600570
  12. Shieh SY, Ikeda M, Taya Y, Prives C. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell. 1997 Oct 31;91(3):325-34. PMID: https://www.ncbi.nlm.nih.gov/pubmed/9363941
  13. 13.0 13.1 13.2 13.3 Murphy M, Ahn J, Walker KK, Hoffman WH, Evans RM, Levine AJ, George DL. Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a. Genes Dev. 1999 Oct 1;13(19):2490-501. PMID: https://www.ncbi.nlm.nih.gov/pubmed/10521394
  14. IARC TP53 mutation database; Note: Somatic and germline TP53 mutations in human cancers http://www-p53.iarc.fr/
  15. 53 web site at the institut Curie http://p53.free.fr/
  16. Atlas of genetics & cytogenetics in oncology & haematology http://atlasgeneticsoncology.org/genes/P53ID88.html
  17. GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=TP53
  18. SHMPD: The Singapore human mutation and polymorphism database http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=TP53
  19. Wikipedia; Note: P53 entry http://en.wikipedia.org/wiki/P53
  20. UniProt http://www.uniprot.org/uniprot/P04637.html
  21. Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7157

Database