CDKN2A-interacting protein (collaborator of ARF, CDKN2AIP, CARF)

Function

• activates TP53/p53 by CDKN2A-dependent & CDKN2A-independent pathways
• interacts with CDKN2A/p14ARF, TP53/p53 & MDM2
• may be ubiquitinated

Structure

• belongs to the CARF family
• contains 1 DRBM (double-stranded RNA-binding) domain

Compartment

nucleus, nucleoplasm

Expression

ubiquitously expressed

More general terms

• phosphoprotein
• nuclear protein
• RNA-binding protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5560
• UniProt: http://www.uniprot.org/uniprot/Q9NXV6.html