p16ink4A; cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3; cyclin-dependent kinase 4 inhibitor A; CDK4I; p16-INK4a; p16INK4A; p16-INK4; multiple tumor suppressor 1; MTS-1; p16MTS1 (CDKN2A, CDKN2, MTS1)

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Function

Structure

Alternative splicing

named isoforms=4

Expression

Pathology

Polymorphism

Comparative biology

More general terms

More specific terms

Additional terms

References

  1. 1.0 1.1 Morgan DO. Principles of CDK regulation. Nature. 1995 Mar 9;374(6518):131-4. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7877684
  2. Kamb A, Gruis NA, Weaver-Feldhaus J, Liu Q, Harshman K, Tavtigian SV, Stockert E, Day RS 3rd, Johnson BE, Skolnick MH. A cell cycle regulator potentially involved in genesis of many tumor types. Science. 1994 Apr 15;264(5157):436-40. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8153634
  3. Marx [Research News] Science 264:344 1994
  4. 4.0 4.1 Cordon-Cardo C. Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia. Am J Pathol. 1995 Sep;147(3):545-60. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7677168
  5. Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1029
  6. 6.0 6.1 Jansen V et al, Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a Nature 2006 (Sept 6) http://dx.doi.org/10.1038/nature05159
    Molofsky AV et al, Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during aging. Nature 2006 http://dx.doi.org/10.1038/nature05091
    Krishnamurthy J et al, p16INK4a induces age-dependent decline in islet regenerative potential Nature 2006 http://dx.doi.org/10.1038/nature05092
  7. CDKN2A Database Database of CDKN2A germline & somatic variants https://biodesktop.uvm.edu/perl/p16
  8. Atlas of genetics & cytogenetics in oncology & haematology http://atlasgeneticsoncology.org/genes/CDKN2aID146.html
  9. GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=CDKN2A
  10. Wikipedia; P16INK4a entry http://en.wikipedia.org/wiki/P16INK4a
  11. UniProt http://www.uniprot.org/uniprot/P42771.html
  12. CDKN2A Database Database of CDKN2A germline & somatic variants
  13. Atlas of genetics & cytogenetics in oncology & haematology http://atlasgeneticsoncology.org/genes/CDKN2aID146.html
  14. GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=CDKN2A
  15. NIEHS-SNPs http://egp.gs.washington.edu/data/cdkn2a/
  16. 16.0 16.1 16.2 Baker DJ, Wijshake T, Tchkonia T Clearance of p16Ink4a-positive senescent cells delays ageing- associated disorders. Nature. 2011 Nov 2;479(7372):232-6 PMID: https://www.ncbi.nlm.nih.gov/pubmed/22048312
    Peeper DS. Old cells under attack. Nature. 2011 Nov 2;479(7372):186 PMID: https://www.ncbi.nlm.nih.gov/pubmed/22071762
  17. Sousa-Victor P et al. Geriatric muscle stem cells switch reversible quiescence into senescence. Nature 2014 Feb 20; 506:316. PMID: https://www.ncbi.nlm.nih.gov/pubmed/24522534
  18. 18.0 18.1 Naylor RM, Baker DJ, van Deursen JM. Senescent cells: a novel therapeutic target for aging and age-related diseases. Clin Pharmacol Ther. 2013 Jan;93(1):105-16 PMID: https://www.ncbi.nlm.nih.gov/pubmed/23212104
  19. Burd CE, Sorrentino JA, Clark KS et al Monitoring tumorigenesis and senescence in vivo with a p16(INK4a)-luciferase model. Cell. 2013 Jan 17;152(1-2):340-51. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23332765 Free PMC Article
    LaPak KM, Burd CE. The molecular balancing act of p16(INK4a) in cancer and aging. Mol Cancer Res. 2014 Feb;12(2):167-83. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/24136988 Free PMC Article

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