melanoma
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Introduction
malignant tumor of melanocytic origin.
Etiology
[1]
- cutaneous melanoma (85%)
- other sites (15%)
- intraocular melanoma (12%)
- vulva (1%)
- others (0.1-1%)
- soft tissues, anus, rectum, vagina, mouth[4], GI tract, upper respiratory tract, bronchus*[5] (images)
- others < 0.1%
- lung, lip, penis, genitourinary, napsopharynx
* melanoma of bronchus probably metastatic from skin despite negative lymph nodes[5]
Immunophenotype
- S100 +
- vimentin +
- HMB45 +
- melan A +
- microphthalmia associated transcription factor (nucleus)
- most non sarcomatoid +
- spindle cell/desmoplastic less positive staining
Laboratory
Management
- treatment of melanoma of the bronchus with trametinib & dabrafenib[5]
More general terms
More specific terms
References
- ↑ Internal Medicine News: March 1, 2005, pg 23 Terrance O'Grady, Scrips Clinic
- ↑ 2.0 2.1 Lange JR, Palis BE, Chang DC, Soong SJ, Balch CM. Melanoma in children and teenagers: an analysis of patients from the National Cancer Data Base. J Clin Oncol. 2007 Apr 10;25(11):1363-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/17416855
- ↑ ARUP Consult: Melanoma The Physician's Guide to Laboratory Test Selection & Interpretation https://www.arupconsult.com/content/melanoma
- ↑ 4.0 4.1 Song JY Intraoral Malignant Melanoma N Engl J Med 2015; 372:1944. May 14, 2015 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/25970052 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMicm1410451
- ↑ 5.0 5.1 5.2 5.3 Manley C, Olszanski A. Melanoma in the Bronchus N Engl J Med 2018; 379:e36. Nov 15, 2018 PMID: https://www.ncbi.nlm.nih.gov/pubmed/30428282 https://www.nejm.org/doi/full/10.1056/NEJMicm1805380