cell-free (circulating tumor) DNA in plasma (liquid biopsy, cFDNA, ctDNA)

From Aaushi
Jump to navigation Jump to search

Indications

Methods

Procedure

* liquid biopsy plus confirmatory imaging sensitivity 27%, specificity 99%, with positive predictive value of 41%[4]

Notes

More general terms

More specific terms

References

  1. 1.0 1.1 Phallen J, Sausen M, Adleff V et al Direct detection of early-stage cancers using circulating tumor DNA. Science Translational Medicine. 16 Aug 2017: 9(403):eaan2415 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/28814544 <Internet> http://stm.sciencemag.org/content/9/403/eaan2415
  2. Corcoran RB, Chabner BA. Application of Cell-free DNA Analysis to Cancer Treatment. N Engl J Med 2018; 379:1754-1765. Nov 1. PMID: https://www.ncbi.nlm.nih.gov/pubmed/30380390 https://www.nejm.org/doi/full/10.1056/NEJMra1706174
  3. 3.0 3.1 Shen SY, Singhania R, Fehringer G et al. Sensitive tumour detection and classification using plasma cell-free DNA methylomes. Nature 2018 Nov 22; 563:579 PMID: https://www.ncbi.nlm.nih.gov/pubmed/30429608 https://www.nature.com/articles/s41586-018-0703-0
  4. 4.0 4.1 Lennon AM, Buchanan AH, Kinde I et al. Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention. Science 2020 Apr 28; [e-pub] PMID: https://www.ncbi.nlm.nih.gov/pubmed/32345712 https://science.sciencemag.org/content/early/2020/04/27/science.abb9601
  5. Bradley SH, Barclay ME. "Liquid biopsy" for cancer screening. BMJ. 2021 Jan 4;372:m4933. PMID: https://www.ncbi.nlm.nih.gov/pubmed/33397684
  6. 6.0 6.1 Bankhead C Liquid Biopsy Predicts Colon Cancer Relapse Months Before CT - Test for ctDNA outperformed existing biomarker, may help guide therapy. MedPage Today January 17, 2021 https://www.medpagetoday.com/meetingcoverage/mgics/90745
    Henriksen TV et al Circulating tumor DNA analysis for assessment of recurrence risk, benefit of adjuvant therapy, and early relapse detection after treatment in colorectal cancer patients. Gastrointestinal Cancers Symposium (GICS) 2021
  7. 7.0 7.1 Krebs MG, Malapelle U, Andre F et al Practical Considerations for the Use of Circulating Tumor DNA in the Treatment of Patients With Cancer. A Narrative Review. JAMA Oncol. Published online October 20, 2022. PMID: https://www.ncbi.nlm.nih.gov/pubmed/36264554 https://jamanetwork.com/journals/jamaoncology/fullarticle/2797725
  8. 8.0 8.1 Carr DJ, Welch G Assessing the Clinical Utility of Liquid Biopsies Across 5 Potential Indications From Therapy Selection to Population Screening. A Review. JAMA Intern Med. Published online August 28, 2023 PMID: https://www.ncbi.nlm.nih.gov/pubmed/37639262 https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2808647