trametinib (Mekinist)

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Indications

* may be used in combination with dabrafenib[2][3]

Contraindications

Adverse effects

Mechanism of action

More general terms

References

  1. FDA News Release: May 29, 2013 FDA approves two drugs, companion diagnostic test for advanced skin cancer. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm354199
  2. 2.0 2.1 2.2 Novartis: Tafinlar (dabrafenib) + Mekinist (trametinib) http://www.hcp.novartis.com/products/tafinlar-mekinist/advanced-metastatic-melanoma/
  3. 3.0 3.1 3.2 Planchard D, Smit EF, Groen HJM et al Dabrafenib plus trametinib in patients with previously untreated BRAF-V600E-mutant metastatic non-small-cell lung cancer: an open-label, phase 2 trial. Lancet Oncol. 2017 Oct;18(10):1307-1316. PMID: https://www.ncbi.nlm.nih.gov/pubmed/28919011
  4. Prescribing Information https://www.pharma.us.novartis.com/sites/www.pharma.us.novartis.com/files/mekinist.pdf

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