small inhibitory antineoplastic agent (ib drug)

Indications

• treatment of malignancy

Dosage

• oral agents

Mechanism of action

• protein inhibitors, often enzyme inhibitors

Notes

• other small inhibitory molecules may have actions different from antineoplastic agents
  • anacetrapib, evacetrapib, dalcetrapib, torcetrapib (anti-hyperlipidemic agents)
  • tofacitinib (DMARD)
  • celecoxib, rofecoxib, valdecoxib, parecoxib, etoricoxib, lumiracoxib (COX2 inhibitors)

More general terms

• antineoplastic agent (chemotherapeutic agent)

More specific terms

• abemaciclib (Verzenio)
• abrocitinib (Cibinqo)
• acalabrutinib (Calquence)
• adagrasib (Krazati)
• afatinib (Gilotrif)
• alectinib (Alecensa)
• alisertib (Aurora A kinase inhibitor MLN8237)
• alpelisib (Piqray)
• asciminib (Scemblix)
• avapritinib (Ayvakit)
• axitinib (Inlyta)
• binimetinib
• bortezomib (Velcade)
• brigatinib (Alunbrig)
• cabozantinib (Cometriq, Cabometyx, XL184)
• capivasertib (Truqap)
• capmatinib (Tabrecta)
• carfilzomib (YU101, CFZ, Kyprolis)
• ceritinib; pelitinib (Zykadia)
• cobimetinib
• copanlisib (Aliqopa)
• crizotinib (Xalkori)
• dabrafenib (Tafinlar)
• dacomitinib (Vizimpro)
• dasatinib (Sprycel)
• deuruxolitinib (Leqselvi)
• duvelisib (Copiktra)
• enasidenib (Idhifa)
• encorafenib (Mektovi)
• entrectinib (Rozlytrek)
• erdafitinib (Balversa)
• erlotinib (Tarceva)
• fedratinib (Inrebic)
• filgotinib (Jyseleca)
• fostamatinib (Tavalisse)
• fruquintinib
• futibatinib (Lytgobi)
• gefitinib (Iressa)
• glasdegib (Daurismo)
• ibrutinib (Imbruvica)
• idelalisib (Zydelig)
• imatinib (Gleevec)
• inavolisib (Itovebi)
• infigratinib (Truseltiq)
• iniparib
• ivosidenib (Tibsovo)
• ixazomib (Ninlaro)
• Janus kinase inhibitor; JAK inhibitor
• lapatinib (Tykerb)
• larotrectinib
• leniolisib (Joenja)
• lenvatinib (Lenvima)
• lonafarnib (Sarasar)
• lorlatinib (Lorbrena)
• masitinib (Masican)
• mirdametinib
• mobocertinib (Exkivity)
• neratinib (Nerlynx)
• nilotinib (Tasigna)
• nintedanib; vargatef (Ofev, BIBF-1120)
• niraparib (Zejula)
• olaparib (Lynparza)
• olutasidenib (Rezlidhia)
• osimertinib (Tagrisso)
• pacritinib (Vonjo)
• palbociclib (Ibrance)
• pazopanib (Votrient)
• pegaptanib
• pemigatinib (Pemazyre)
• pexidartinib (Turalio)
• pirtobrutinib (Jaypirca)
• ponatinib (Iclusig)
• pralsetinib (Gavreto)
• quizartinib (Vanflyta)
• regorafenib (BAY 73-4506, Stivarga)
• repotrectinib (Augtyro)
• revumenib
• ribociclib (Kisqali)
• ripretinib (Qinlock)
• rucaparib (Rubraca)
• ruxolitinib (Jakafi, Opzelura)
• selpercatinib (Retevmo)
• selumetinib (Koselugo, AZD6244)
• semaxinib (SU5416)
• sonidegib (Odomzo)
• sotorasib (Lumakras)
• talazoparib (Talzenna)
• taselisib
• tepotinib (Tepmetko)
• tivozanib (Fotivda, AV-951)
• toceranib (Palladia)
• trametinib (Mekinist)
• trilaciclib (Cosela)
• tucatinib; irbinitinib (Tukysa)
• umbralisib (Ukoniq)
• vandetanib (Caprelsa)
• veliparib
• vemurafenib (Zelboraf, PLX4032)
• vismodegib (Erivedge)
• vorasidenib (Servier)
• zanubrutinib (Brukinsa)

Additional terms

• anacetrapib
• celecoxib (Celebrex)
• dalcetrapib (JTT-705)
• darapladib
• etoricoxib (Arcoxia)
• evacetrapib
• lumiracoxib (Prexige)
• parecoxib (Dynastat)
• rofecoxib (Vioxx)
• tofacitinib (Xeljanz)
• torcetrapib
• valdecoxib (Bextra)