sonidegib (Odomzo)

Indications

• treatment of locally advanced basal cell carcinoma
  • indicated for adults for whom surgery or radiation isn't an option, or for basal cell carcinoma recurrence after surgery or radiation

Contraindications

• pregnancy

Dosage

• 200 mg PO QD

Adverse effects

• muscle spasms
• alopecia
• dysgeusia
• fatigue
• nausea/vomiting
• musculoskeletal pain
• diarrhea
• weight loss
• anorexia
• myalgia
• abdominal pain,
• headache
• pain
• pruritus
• rhabdomyolysis

Mechanism of action

• inhibits Hedgehog pathway

More general terms

• small inhibitory antineoplastic agent (ib drug)

Additional terms

• vismodegib (Erivedge)