fatigue; lassitude; tiredness

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Etiology

Clinical manifestations

  • manifestations suggesting organic etiology
    • duration of < 4 weeks
    • progressive deterioration
  • manifestations suggesting psychosocial etiology
    • duration of symptoms > 4 months
    • peak symptomatology in AM
    • non-specific & multiple symptoms

Laboratory

Diagnostic procedures

Complications

  • not strongly associated with increased mortality

Differential diagnosis

Management

More general terms

Additional terms

References

  1. Saunders Manual of Medical Practice, Rakel (ed), WB Saunders, Philadelphia, 1996, pg 1090-92
  2. 2.0 2.1 2.2 Medical Knowledge Self Assessment Program (MKSAP) 11, 16, 18, 19. American College of Physicians, Philadelphia 1998, 2012, 2018, 2021.
  3. Abrahm JL A Physician's Guide to Pain and Symptom Management in Cancer Patients,2nd ed, Baltimore, MD, Johns Hopkins University Press, 2005
  4. Nijrolder I, van der Horst H, van der Windt D. Prognosis of fatigue. A systematic review. J Psychosom Res. 2008 Apr;64(4):335-49. PMID: https://www.ncbi.nlm.nih.gov/pubmed/18374732
  5. Alexander NB, Taffet GE, Horne FM Bedside-to-Bench conference: research agenda for idiopathic fatigue and aging. J Am Geriatr Soc. 2010 May;58(5):967-75. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20722821 Free PMC Article
  6. Murphy SL, Alexander NB, Levoska M, Smith DM. Relationship between fatigue and subsequent physical activity among older adults with symptomatic osteoarthritis. Arthritis Care Res (Hoboken). 2013 Oct;65(10):1617-24. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23592576 Free PMC Article
  7. Schnelle JF, Buchowski MS, Ikizler TA Evaluation of two fatigability severity measures in elderly adults. J Am Geriatr Soc. 2012 Aug;60(8):1527-33. PMID: https://www.ncbi.nlm.nih.gov/pubmed/22860899 Free PMC Article