modafinil (Provigil, Sparlon)

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Introduction

DEA-controlled substance: class 4. (racemic mixture)

Indications

Contraindications

pregnancy category = c/d/x?

safety in lactation = ?

Dosage

Reduce dosage 50% with liver impairment

Pharmacokinetics

elimination via liver

1/2life = 7-14 hours

protein binding = 60 %

Adverse effects

Drug interactions

Mechanism of action

More general terms

More specific terms

Additional terms

References

  1. Micromedex
  2. Prescriber's Letter 7(7):41 2000
  3. 3.0 3.1 3.2 3.3 Prescriber's Letter 8(3):16 2001
  4. Prescriber's Letter 13(3): 2006 Cytochrome P450 drug interactions Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=220233&pb=PRL (subscription needed) http://www.prescribersletter.com
  5. 5.0 5.1 Journal Watch 22(2):17, 2002 Pack et al, Am J Respir Crit Care Med 164:1675, 2001
  6. Czeisler CA, Walsh JK, Roth T, Hughes RJ, Wright KP, Kingsbury L, Arora S, Schwartz JR, Niebler GE, Dinges DF; U.S. Modafinil in Shift Work Sleep Disorder Study Group. Modafinil for excessive sleepiness associated with shift-work sleep disorder. N Engl J Med. 2005 Aug 4;353(5):476-86. Erratum in: N Engl J Med. 2005 Sep 8;353(10):1078. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16079371
    Basner RC. Shift-work sleep disorder--the glass is more than half empty. N Engl J Med. 2005 Aug 4;353(5):519-21. No abstract available. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16079378
  7. 7.0 7.1 Prescriber's Letter 13(2): 2006 Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=220214&pb=PRL (subscription needed) http://www.prescribersletter.com
  8. 8.0 8.1 8.2 8.3 8.4 8.5 Morgenthaler TI et al, Practice parameters for the treatment of narcolepsy and other hypersomnias of central origin. Sleep 2007, 30:1705 PMID: https://www.ncbi.nlm.nih.gov/pubmed/18246980
  9. FDA MedWatch Updates to the WARNINGS section of the prescribing information http://www.fda.gov/medwatch/safety/2007/safety07.htm#Provigil
    Prescriber's Letter 14(12): 2007 Safety Warning with Modafinil Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=231210&pb=PRL (subscription needed) http://www.prescribersletter.com
  10. 10.0 10.1 Medical Knowledge Self Assessment Program (MKSAP) 16 American College of Physicians, Philadelphia 2012
  11. 11.0 11.1 Deprecated Reference
  12. 12.0 12.1 Damkier P, Broe A. First-Trimester Pregnancy Exposure to Modafinil and Risk of Congenital Malformations. JAMA. 2020;323(4):374-376. PMID: https://www.ncbi.nlm.nih.gov/pubmed/31990303 https://jamanetwork.com/journals/jama/article-abstract/2759460

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