desipramine (Norpramin, Pertofrane)

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Introduction

Tradenames: Norpramin, Pertofrane.

Indications

Contraindications

Caution:

  • avoid ingestion of alcohol
  • do not discontinue medication abruptly

pregnancy category = c

safety in lactation = ?

Dosage

  • start 25-200 mg PO QHS or in divided doses
  • usual maintenance dose is 75-150 mg/day
  • max 300 mg/day

Tabs: 10, 25, 50, 75, 100, 150 mg.

Pharmacokinetics

elimination via liver

1/2life = 20-90 hours

protein binding = 73-92 %

elimination by hemodialysis = -

elimination by hemoperfusion = -

elimination by peritoneal dialysis = -

Adverse effects

Drug interactions

Laboratory

Mechanism of action

More general terms

Additional terms

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. 2.0 2.1 Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  3. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  4. Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995
  5. Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 56
  6. 6.0 6.1 FDA MedWatch Norpramin (desipramine hydrochloride) - Dear Healthcare Professional Letter http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm192655.htm
  7. 7.0 7.1 7.2 Deprecated Reference

Database