tricyclic antidepressant (TCA)

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Indications

Contraindications

Dosage

  • low-dose (< 100 mg/day) may be effective, with reduced risk of adverse effects[1]

Pharmacokinetics

  • metabolism by cyt P450 2D6 > 2C9, 2C10, 2C19
  • slow onset of action with several weeks to achieve full effects

Adverse effects

Overdose:

Drug interactions

Laboratory

Mechanism of action

More general terms

More specific terms

Additional terms

References

  1. 1.0 1.1 Journal Watch 23(1):11, 2003 Furukawa TA et al, Meta-analysis of effects and side effects of low dosage tricyclic antidepressants in depression: systematic review BMJ 325:991, 2002 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/12411354 <Internet> http://bmj.com/cgi/content/full/325/7371/991
  2. 2.0 2.1 Medications Can Cause Seizures Prescriber's Letter 10(3):16 2003 Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=190320&pb=PRL (subscription needed) http://www.prescribersletter.com
  3. 3.0 3.1 3.2 Medical Knowledge Self Assessment Program (MKSAP) 14, 15, 16, 18 American College of Physicians, Philadelphia 2006, 2009, 2012, 2018.
  4. The Washington Manual of Medical Therapeutics, 33rd edition Foster C et al (eds) Lippincott, Williams & Wilkins, Philadelphia, 2010, pg 957
  5. 5.0 5.1 Body R, Bartram T, Azam F, Mackway-Jones K. Guidelines in Emergency Medicine Network (GEMNet): guideline for the management of tricyclic antidepressant overdose. Emerg Med J. 2011 Apr;28(4):347-68 PMID: https://www.ncbi.nlm.nih.gov/pubmed/21436332
  6. 6.0 6.1 Goldstein JN, Dudzinski DM, Erickson TB, Linder G. Case 12-2018: A 30-Year-Old Woman with Cardiac Arrest. N Engl J Med 2018; 378:1538-1549. April 19, 2018 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/29669228 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMcpc1800322
  7. 7.0 7.1 NEJM Knowledge+ Question of the Week. December 18, 2018 https://knowledgeplus.nejm.org/question-of-week/803/