tricyclic antidepressant (TCA)

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Indications

Contraindications

Dosage

  • low-dose (< 100 mg/day) may be effective, with reduced risk of adverse effects[1]

Pharmacokinetics

  • metabolism by cyt P450 2D6 > 2C9, 2C10, 2C19
  • slow onset of action with several weeks to achieve full effects

Adverse effects

Overdose:

Drug interactions

Laboratory

Mechanism of action

More general terms

More specific terms

Additional terms

References

  1. Jump up to: 1.0 1.1 Journal Watch 23(1):11, 2003 Furukawa TA et al, Meta-analysis of effects and side effects of low dosage tricyclic antidepressants in depression: systematic review BMJ 325:991, 2002 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/12411354 <Internet> http://bmj.com/cgi/content/full/325/7371/991
  2. Jump up to: 2.0 2.1 Medications Can Cause Seizures Prescriber's Letter 10(3):16 2003 Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=190320&pb=PRL (subscription needed) http://www.prescribersletter.com
  3. Jump up to: 3.0 3.1 3.2 Medical Knowledge Self Assessment Program (MKSAP) 14, 15, 16, 18 American College of Physicians, Philadelphia 2006, 2009, 2012, 2018.
  4. The Washington Manual of Medical Therapeutics, 33rd edition Foster C et al (eds) Lippincott, Williams & Wilkins, Philadelphia, 2010, pg 957
  5. Jump up to: 5.0 5.1 Body R, Bartram T, Azam F, Mackway-Jones K. Guidelines in Emergency Medicine Network (GEMNet): guideline for the management of tricyclic antidepressant overdose. Emerg Med J. 2011 Apr;28(4):347-68 PMID: https://www.ncbi.nlm.nih.gov/pubmed/21436332
  6. Jump up to: 6.0 6.1 Goldstein JN, Dudzinski DM, Erickson TB, Linder G. Case 12-2018: A 30-Year-Old Woman with Cardiac Arrest. N Engl J Med 2018; 378:1538-1549. April 19, 2018 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/29669228 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMcpc1800322
  7. Jump up to: 7.0 7.1 NEJM Knowledge+ Question of the Week. December 18, 2018 https://knowledgeplus.nejm.org/question-of-week/803/