drug interaction(s) of NSAIDs with antidepressants

^[1]

Drug interactions

increased risk of intracranial hemorrhage (NNH=244)
- no differences among the various antidepressant classes^[1]
- relative risk > for men than women
  - RR = 2.6 (men) vs 1.2 (women)

↑ ^1.0 ^1.1 Shin JY, Park MJ, Lee SH et al Risk of intracranial haemorrhage in antidepressant users with concurrent use of non-steroidal anti-inflammatory drugs: nationwide propensity score matched study. BMJ 2015;351:h3517 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/26173947 <Internet> http://www.bmj.com/content/351/bmj.h3517
Mercer SW et al Risk of intracranial haemorrhage linked to co-treatment with antidepressants and NSAIDs. BMJ 2015;351:h3745 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/26173949 <Internet> http://www.bmj.com/content/351/bmj.h3745