cytochrome P450 2D6 (cytochrome P450 2D, cytochrome P450 DB1, debrisoquine-4-hydroxylase, CYP2D6)
Jump to navigation
Jump to search
Function
- responsible for the metabolism of many drugs & environmental chemicals
- metabolism of codeine, dihydrocodeine, hydrocodone & tramadol by cyt P450 2D6 are necessary for conversion to an active analgesic metabolite
- inducers
- not inducible
- inhibitors
- amiodarone
- asenapine
- bupropion
- celecoxib
- chloramphenicol
- chloroquine
- chlorpheniramine
- cimetidine
- cinacalcet
- citalopram
- clemastine
- clomipramine
- cocaine
- darifenacin
- darunavir
- desipramine
- diphenhydramine
- doxepin
- doxorubicin
- dronedarone
- duloxetine
- escitalopram
- everolimus
- fluoxetine
- fluphenazine
- fluvoxamine
- halofantrine
- haloperidol
- hydroxychloroquine
- iloperidone
- imatinib
- methadone
- nicardipine
- paroxetine
- perphenazine
- Piper methysticum (Kava-kava)
- pomegranate
- propafenone
- propoxyphene
- propranolol
- quinacrine
- quinidine
- quinine
- ranitidine
- ranolazine
- ritonavir
- rolapitant
- sertraline
- terbinafine
- thioridazine
- ticlopidine
- tipranavir
- tripelennamine
- substrates
- amitriptyline
- amphetamine
- asenapine
- atomoxetine
- bisoprolol
- carvedilol
- cevimeline
- chlorpromazine
- chlorpropamide
- ciclesonide
- cinacalcet
- clomipramine
- clozapine
- codeine
- cyclobenzaprine
- darifenacin
- desipramine
- dexfenfluramine
- dextromethorphan
- dolasetron
- donepezil
- doxepin
- duloxetine
- encainide
- fenfluramine
- fentanyl
- fesoterodine
- flecainide
- fluoxetine
- fluphenazine
- fluvoxamine
- formoterol
- galantamine
- haloperidol
- hydrocodone
- iloperidone
- imipramine
- lidocaine
- maprotiline
- meperidine
- methadone
- methamphetamine
- metoprolol
- mexiletine
- mirtazapine
- morphine
- nebivolol
- nortriptyline
- olanzapine
- ondansetron
- oxycodone
- paroxetine
- perphenazine
- pindolol
- propafenone
- propoxyphene
- propranolol
- quetiapine
- ranolazine
- risperidone
- ritonavir
- tamoxifen
- tetrabenazine
- thioridazine
- timolol
- tolterodine
- tramadol
- trazodone
- venlafaxine
Compartment
membrane-bound, endoplasmic reticulum
Expression
Inhibition:
Polymorphism
- highly polymorphic
- 7% of Caucasians & 2% of Asians have reduced cyt P450 2D6 activity (poor metabolizers of cyt P450 2D6-metabolized drugs)[6]
- allele CYP2D6*7 was also known as CYP2D6E allele CYP2D6*9 as CYP2D6C allele CYP2D6*10 as CYP2D6J allele CYP2D6*17 as CYP2D6Z
Laboratory
More general terms
Additional terms
References
- ↑ OMIM https://mirror.omim.org/entry/124030
- ↑ UniProt http://www.uniprot.org/uniprot/P10635.html
- ↑ Tarascon Pharmacopoeia, 2001
- ↑ Pirmohamed M & Park BK, Toxicology 192:23-32, 2003
- ↑ Prescriber's Letter 11(4):24 2004
- ↑ 6.0 6.1 http://pi.lilly.com/us/strattera-pi.pdf
- ↑ Prescriber's Letter 13(3): 2006 Cytochrome P450 drug interactions Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=220233&pb=PRL (subscription needed) http://www.prescribersletter.com
- ↑ Cytochrome P450 Allele Nomenclature committee, CYP2D6 alleles http://www.cypalleles.ki.se/cyp2d6.htm
- ↑ Wikipedia, CYP2D6 entry http://en.wikipedia.org/wiki/CYP2D6
- ↑ 10.0 10.1 Prescriber's Letter 17(1): 2010 Cytochrome P450 Drug Interactions CHART: Cytochrome P450 Drug Interactions COMMENTARY: Proton Pump Inhibitor and Plavix Interaction: An Update Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=260112&pb=PRL (subscription needed) http://www.prescribersletter.com
- ↑ Prescriber's Letter 18(3): 2011 CHART: Cytochrome P450 Drug Interactions Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=270307&pb=PRL (subscription needed) http://www.prescribersletter.com