mirtazapine (Remeron)

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Introduction

Tradename: Remeron

Indications

* not useful for treatment of obstructive sleep apnea[5][6]

Contraindications

pregnancy category = c

safety in lactation = ?

Dosage

Tabs: 7.5, 15 & 30 mg.

Pharmacokinetics

elimination via liver

elimination via kidney

1/2life = 20-40 hours

protein binding = 85 %

Adverse effects

Overdose: No specific antidotes for overdose.

Drug interactions

Mechanism of action

More general terms

Additional terms

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Physician's Desk Reference (PDR) 54th edition, Medical Economics, 2000
  3. Bronstein J. In: Intensive Course in Geriatric Medicine & Board Review, Marina Del Ray, CA, Sept 12-15, 2001
  4. 4.0 4.1 Journal Watch 24(14):116, 2004 Bendtsen L, Jensen R. Mirtazapine is effective in the prophylactic treatment of chronic tension-type headache. Neurology. 2004 May 25;62(10):1706-11. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15159466
  5. 5.0 5.1 5.2 Geriatric Review Syllabus, 7th edition Parada JT et al (eds) American Geriatrics Society, 2010
    Geriatric Review Syllabus, 8th edition (GRS8) Durso SC and Sullivan GN (eds) American Geriatrics Society, 2013
    Geriatric Review Syllabus, 11th edition (GRS11) Harper GM, Lyons WL, Potter JF (eds) American Geriatrics Society, 2022
  6. 6.0 6.1 6.2 Marshall NS, Yee BJ, Desai AV et al Two randomized placebo-controlled trials to evaluate the efficacy and tolerability of mirtazapine for the treatment of obstructive sleep apnea. Sleep. 2008 Jun;31(6):824-31. PMID: https://www.ncbi.nlm.nih.gov/pubmed/18548827
  7. 7.0 7.1 Gafoor R, Booth HP, Gulliford MC. Antidepressant utilisation and incidence of weight gain during 10 years' follow-up: population based cohort study. BMJ 2018;361:k1951 PMID: https://www.ncbi.nlm.nih.gov/pubmed/29793997 Free full text https://www.bmj.com/content/361/bmj.K1951
  8. 8.0 8.1 8.2 Talebraza S et al Geriatrics Evaluation & Management Tools American Geriatrics Society. 2021 https://geriatricscareonline.org/ProductAbstract/geriatrics-evaluation-management-tools/B007/
  9. Department of Veterans Affairs, VA National Formulary

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