clonidine (Catapres)

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Introduction

Tradename: Catapres. (clonidine hydrochloride)

Indications

Contraindications

pregnancy category = c

safety in lactation = ?

Dosage

Tabs: 0.1, 0.2. 0.3 mg.

Transdermal (Catepres-TTS) 1 patch weekly.

Patches: 0.1, 0.2, 0.3 mg/day.

Hypertensive urgency:

  • 0.2 mg PO loading dose, then 0.1 mg hourly up to 0.6 mg.
  • Na+ retention occurs, thus a single dose of a diuretic is frequently used after clonidine loading.

Pharmacokinetics

elimination via kidney

elimination via liver

1/2life = 5-23 hours

protein binding = 20-40 %

elimination by hemodialysis = -

Adverse effects

Drug interactions

Laboratory

Mechanism of action

More general terms

Additional terms

Component of

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  3. 3.0 3.1 Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  4. Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995
  5. Geriatric Dosage Handbook, 6th edition, Selma et al eds, Lexi-Comp, Cleveland, 2001
  6. 6.0 6.1 Prescriber's Letter 17(3): 2010 Clonidine Abuse Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=260305&pb=PRL (subscription needed) http://www.prescribersletter.com
  7. 7.0 7.1 Deprecated Reference
  8. 8.0 8.1 Corazza M, Mantovani L, Virgili A, Strumia R. Allergic contact dermatitis from a clonidine transdermal delivery system. Contact Dermatitis. 1995 Apr;32(4):246. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7600788

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