prazosin (Minipress, Deprazolin)

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Introduction

Tradename: Minipress.

Indications

Contraindications

pregnancy category = c

safety in lactation = ?

Dosage

Tabs: 1,2 5 mg.

* The 1st dose of prazosin may cause hypotension & syncope, thus it should be given before bedtime.

Pharmacokinetics

elimination via liver

1/2life = 2-4 hours

Adverse effects

Drug interactions

Laboratory

Mechanism of action

More general terms

Component of

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
  3. Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 474
  4. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  5. 5.0 5.1 Dierks MR et al, Prozosin treatment of nightmares related to postraumatic stress disorder. Ann Pharmacother 2007, 41:1013 PMID: https://www.ncbi.nlm.nih.gov/pubmed/17504838
  6. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  7. 7.0 7.1 7.2 Raskind MA et al. Trial of prazosin for post-traumatic stress disorder in military veterans. N Engl J Med 2018 Feb 8; 378:507 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/29414272 <Internet> http://www.nejm.org/doi/10.1056/NEJMoa1507598
    Ressler KJ. Alpha-adrenergic receptors in PTSD - Failure or time for precision medicine? N Engl J Med 2018 Feb 8; 378:575 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/29414268 <Internet> http://www.nejm.org/doi/10.1056/NEJMe1716724

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