beta adrenergic receptor antagonist (beta-blocker)

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Introduction

A molecule/drug that blocks the effect of catecholamines on beta adrenergic receptors, producing a decrease in heart rate & oxygen demand in the myocardium.

Indications

* no advantage of beta-blockers for preventing myocardial infarction or death when used to treat hypertension[9] or in patients with stable coronary artery disease or cardiovascular risk factors[14]

# not 1st line for uncomplicated hypertension[12]

Contraindications

Caution:

Adverse effects

Overdose:

Drug interactions

Laboratory

Mechanism of action

More general terms

More specific terms

Additional terms

Component of

References

  1. Jump up to: 1.0 1.1 Medical Knowledge Self Assessment Program (MKSAP) 11, 15, 16. American College of Physicians, Philadelphia 1998 2009, 2012
  2. Jump up to: 2.0 2.1 Manual of Medical Therapeutics, 28th ed, Ewald & McKenzie (eds), Little, Brown & Co, Boston, 1995, pg 158-59
  3. Jump up to: 3.0 3.1 Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 474-75, 491
  4. Jump up to: 4.0 4.1 The Washington Manual of Medical Therapeutics, 33rd edition Foster C et al (eds) Lippincott, Williams & Wilkins, Philadelphia, 2010, pg 969
  5. Jump up to: 5.0 5.1 Journal Watch 20(9): 72, 2000 Gress TW, Nieto FJ, Shahar E, Wofford MR, Brancati FL. Hypertension and antihypertensive therapy as risk factors for type 2 diabetes mellitus. Atherosclerosis Risk in Communities Study. N Engl J Med. 2000 Mar 30;342(13):905-12. PMID: https://www.ncbi.nlm.nih.gov/pubmed/10738048
  6. Prescriber's Letter 12(4): 2005 Comparison of Beta-Blockers Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=210410&pb=PRL (subscription needed) http://www.prescribersletter.com
  7. Jump up to: 7.0 7.1 Prescriber's Letter 12(7): 2005 Should Some Drugs Be Avoided in Patients at Risk of Anaphylaxis? Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=210714&pb=PRL (subscription needed) http://www.prescribersletter.com
  8. Lanfear DE, Jones PG, Marsh S, Cresci S, McLeod HL, Spertus JA. Beta2-adrenergic receptor genotype and survival among patients receiving beta-blocker therapy after an acute coronary syndrome. JAMA. 2005 Sep 28;294(12):1526-33. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16189366
  9. Jump up to: 9.0 9.1 Lindholm LH, Carlberg B, Samuelsson O. Should beta blockers remain first choice in the treatment of primary hypertension? A meta-analysis. Lancet. 2005 Oct 29-Nov 4;366(9496):1545-53. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16257341
    Beevers DG. The end of beta blockers for uncomplicated hypertension? Lancet. 2005 Oct 29-Nov 4;366(9496):1510-2. No abstract available. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16257329
  10. Khan N and McAlister FA, Re-examining the efficacy of beta blockers for treatment of hypertension. A meta-analysis. CMAJ 2006; 174:1737 PMID: https://www.ncbi.nlm.nih.gov/pubmed/16754904
  11. Prescriber's Letter 14(8): 2007 CHART: AHA Blood Pressure Goals and Treatments Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=230801&pb=PRL (subscription needed) http://www.prescribersletter.com
  12. Jump up to: 12.0 12.1 12.2 Bangalore S et sl, Relation of beta-blocker-induced heart rate lowering and cardioprotection in hypertension. J Am Coll Cardiol 2008 52:1482 PMID: https://www.ncbi.nlm.nih.gov/pubmed/19017516
    Kaplan NM Beta-blockers in hypertension: Adding insult to injury. J Am Coll Cardiol 2008 52:1490 PMID: https://www.ncbi.nlm.nih.gov/pubmed/19017517
  13. Prescriber's Letter 14(8): 2007 Comparison of Oral Beta-Blockers Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=250302&pb=PRL (subscription needed) http://www.prescribersletter.com
  14. Jump up to: 14.0 14.1 Bangalore S et al. for the REACH Registry Investigators. beta-blocker use and clinical outcomes in stable outpatients with and without coronary artery disease. JAMA 2012 Oct 3; 308:1340. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23032550
  15. Prescriber's Letter 19(12): 2012 CHART: Comparison of Oral Beta-Blockers Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=281221&pb=PRL (subscription needed) http://www.prescribersletter.com
  16. Jump up to: 16.0 16.1 16.2 Deprecated Reference
  17. Jump up to: 17.0 17.1 Boyles S No Fetal Heart Risk from Mom's Beta-Blocker Use - More complete data point finger at maternal confounders. MedPage Today. April 18, 2017
    Duan L, Ng A, Chen W et al beta-Blocker exposure in pregnancy and risk of fetal cardiac anomalies. JAMA Intern Med. 2017 Apr 17 PMID: https://www.ncbi.nlm.nih.gov/pubmed/28418448
  18. Jump up to: 18.0 18.1 Valdes AM, Abhishek A, Muir K et al Association of Beta-Blocker Use With Less Prevalent Joint Pain and Lower Opioid Requirement in People With Osteoarthritis. Arthritis Care Res (Hoboken). 2017 Jul;69(7):1076-1081. PMID: https://www.ncbi.nlm.nih.gov/pubmed/27696728
  19. Jump up to: 19.0 19.1 Bateman BT, Heide-Jorgensen U, Einarsdottir K et al beta-Blocker Use in Pregnancy and the Risk for Congenital Malformations: An International Cohort Study. Ann Intern Med. 2018. Oct 16. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/30326014 <Internet> http://annals.org/aim/article-abstract/2707333/blocker-use-pregnancy-risk-congenital-malformations-international-cohort-study
    Ray JG To beta of Not to beta? Very likely K to beta. Ann Intern Med. 2018. Oct 16. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/30326080 <Internet> http://annals.org/aim/article-abstract/2707335/very-likely-ok
  20. Jump up to: 20.0 20.1 Riemer TG, Villagomez Fuentes LE, Algharably EAE et al Do beta-Blockers Cause Depression? Hypertension. 2021. March 15 PMID: https://www.ncbi.nlm.nih.gov/pubmed/33719510 https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.120.16590
  21. DeWitt CR, Waksman JC. Pharmacology, pathophysiology and management of calcium channel blocker and beta-blocker toxicity. Toxicol Rev 2004; 23:223 PMID: https://www.ncbi.nlm.nih.gov/pubmed/15898828