calcium chloride

Indications

• cardiac resuscitation: 2-4 mg/kg every 10 min
• cardiac arrest secondary to hyperkalemia
  • 2-4 mg/kg every 10 min
• hypocalcemia:
  • 500 mg - 1 g every 1-3 days as needed
  • hypocalcemic tetany: 4.5-16 meq until response
• treatment of hypermagnesemia
• toxicity from Ca+2 channel blockers

Contraindications

Do NOT:

• administer SC or IM
• administer in same line as phosphate-containing solutions

pregnancy-category :value +

safety-in-lactation :value ?

Dosage

Injection: 100 mg/mL. 10 mL ampules & syringes.

Pharmacokinetics

• eliminated mainly in the feces, 20% eliminated in the urine

Monitor

EKG if infused > 2.5 meq/min

Adverse effects

• uncommon (< 1%)
• vasodilation
• hypotension
• bradycardia
• arrhythmias including ventricular fibrillation
• coma
• mania
• erythema
• tissue necrosis
• muscle weakness
• syncope
• CNS depression including lethargy & coma
• increased serum amylase
• decreased serum Mg+2
• hypercalcemia
• hypercalciuria
• extravasation:
  • treat with hyaluronidase: 15 units/mL, 1mL

• drug adverse effects of calclium supplement(s)

Drug interactions

• may antagonize effects of calcium channel blockers
• may increase digoxin toxicity

• drug interaction(s) of bisphosphonate with Ca+2

Mechanism of action

• moderates nerve conduction & muscle contraction via action potential excitation threshold regulation

More general terms

• calcium supplement
• salt
• metabolic agent (metabolic modifier)

Additional terms

• Hylenex (Wydase, Amphadase, Vitrase, Hydase, hyaluronidase)

Component of

• calcium chloride/sodium fluoride/sodium phosphate
• calcium chloride/potassium chloride/sodium chloride/sodium lactate
• calcium chloride/glucose/potassium chloride/sodium chloride/sodium lactate
• calcium chloride/magnesium chloride/sodium chloride/sodium lactate
• calcium chloride/glucose/magnesium sulfate/potassium chloride/sodium bicarbonate/sodium chloride/sodium phosphate
• calcium chloride/glucose/magnesium chloride/sodium chloride/sodium lactate
• calcium chloride/glucose/magnesium chloride/potassium chloride/sodium bicarbonate/sodium chloride/sodium phosphate
• calcium chloride/glucose/magnesium chloride/potassium chloride/sodium acetate/sodium chloride/sodium lactate
• alanine/arginine/calcium chloride/glucose/glycine/histidine/isoleucine/leucine/magnesium chloride/methionine/phenylalanine/potassium phosphate/proline/serine/sodium acetate/sodium chloride/threonine/tryptophan/tyrosine/valine
• alanine/arginine/calcium chloride/glucose/glycine/histidine/isoleucine/leucine/lysine/magnesium chloride/methionine/phenylalanine/potassium phosphate/proline/serine/sodium acetate/sodium chloride/threonine/tryptophan/tyrosine/valine
• alanine/arginine/aspartate/calcium chloride/glucose/glutamate/glycine/histidine/isoleucine/leucine/lysine/magnesium chloride/methionine/phenylalanine/potassium chloride/potassium phosphate/proline/serine/sodium chloride/threonine/tryptophan/tyrosine/valine
• calcium chloride/magnesium chloride/potassium chloride/sodium acetate/sodium chloride
• calcium chloride/lactate/magnesium chloride/potassium chloride/sodium acetate/sodium chloride
• calcium chloride/citrate/magnesium chloride/potassium chloride/sodium acetate/sodium chloride
• calcium chloride/potassium chloride/sodium chloride
• calcium chloride/lactate/potassium chloride/sodium chloride
• calcium chloride/glucose/potassium chloride/sodium chloride
• calcium chloride/glucose/lactate/potassium chloride/sodium chloride
• calcium chloride/glucose/lactate/magnesium chloride/sodium chloride
• calcium chloride/fibrinogen/fibrinolytic inhibitor/thrombin
• Elliotts B Solution (buffered intrathecal electrolyte/dextrose injection)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=24854
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=24844
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5284359