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Death of tissue.




Necrosis contrasts with apoptosis by an early loss in membrane integrity, leakage of cytoplasmic contents & induction of the inflammatory process. Apoptosis is associated with changes in membrane permeability without membrane disinitegration & without induction of the inflammatory process. Necrosis is pathologic, whereas apoptosis can be pathologic or physiologic.

Necrosis may involve massive activation of poly ADP-ribose polymerase & depletion of NAD & secondarily ATP.[1]

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  2. Okada H, Mak TW. Pathways of apoptotic and non-apoptotic death in tumour cells. Nat Rev Cancer. 2004 Aug;4(8):592-603. Review. No abstract available. PMID:
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