necrosis
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Introduction
Death of tissue.
Etiology
- ischemia
- hypoglycemia
- infection
- inflammation
Pathology
- swelling & rupture of cell
- mitochochondria disintegrate
- ATP is depleted
- disintegration of other organelles
- induction of inflammatory process
Notes
Necrosis contrasts with apoptosis by an early loss in membrane integrity, leakage of cytoplasmic contents & induction of the inflammatory process. Apoptosis is associated with changes in membrane permeability without membrane disinitegration & without induction of the inflammatory process. Necrosis is pathologic, whereas apoptosis can be pathologic or physiologic.
Necrosis may involve massive activation of poly ADP-ribose polymerase & depletion of NAD & secondarily ATP.[1]
More general terms
More specific terms
- avascular necrosis (AVN)
- caseous necrosis
- coagulation necrosis
- colonic necrosis
- enzymatic fat necrosis
- fibrinoid necrosis
- gangrene
- geographic necrosis
- hepatic necrosis
- liquefaction necrosis
- myonecrosis
- oncosis (ischemic cell death)
- osteonecrosis
- pancreatic necrosis
- radiation necrosis
- renal cortical necrosis
- renal papillary necrosis
- skin necrosis
Additional terms
References
- ↑ 1.0 1.1 Sedlak TW, Snyder SH. Messenger molecules and cell death: therapeutic implications. JAMA. 2006 Jan 4;295(1):81-9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16391220
- ↑ Okada H, Mak TW. Pathways of apoptotic and non-apoptotic death in tumour cells. Nat Rev Cancer. 2004 Aug;4(8):592-603. Review. No abstract available. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15286739
- ↑ Danial NN, Korsmeyer SJ. Cell death: critical control points. Cell. 2004 Jan 23;116(2):205-19. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/14744432
- ↑ Syntichaki P, Tavernarakis N. The biochemistry of neuronal necrosis: rogue biology? Nat Rev Neurosci. 2003 Aug;4(8):672-84. Review. No abstract available. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12894242
- ↑ Syntichaki P, Tavernarakis N. Death by necrosis. Uncontrollable catastrophe, or is there order behind the chaos? EMBO Rep. 2002 Jul;3(7):604-9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12101090