NAD (nicotinamide adenine dinucleotide)
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Indications
Mechanism of action
- product of nicotinamide phosphoribosyltransferase
- activates SIRT1 activity[1]
- increases capillary density & blood flow in skeletal muscle of old mice via activation of SIRT1
- NAD-booster NMN mimics & augments exercise by inhibiting NICD-NOTCH (in mice)[2]
- increases endurance in old mice[2]
More general terms
Additional terms
- citric acid cycle, Krebs cycle or tricarboxylic acid [TCA] cycle
- electron transport
- nicotinamide (a vitamin B3, NMN)
- nicotinamide mononucleotide
Component of
References
- ↑ 1.0 1.1 1.2 Imai S A possibility of nutriceuticals as an anti-aging intervention: activation of sirtuins by promoting mammalian NAD biosynthesis. Pharmacol Res. 2010 Jul;62(1):42-7 PMID: https://www.ncbi.nlm.nih.gov/pubmed/20085812 Free PMC Article
- ↑ 2.0 2.1 2.2 Das A, Huang GX, Bonkowski MS et al. Impairment of an endothelial NAD+ -H2S signaling network is a reversible cause of vascular aging. Cell 2018 Mar 22; 173:74-89 PMID: https://www.ncbi.nlm.nih.gov/pubmed/29570999
- ↑ Rajman L, Chwalek K, Sinclair DA. Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence. Cell Metab. 2018 Mar 6;27(3):529-547. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/29514064