notch (Drosophila) homolog protein
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Function
- involved in developmental regulation
- presenilins are involved in Notch cleavage[2]
- leaved to yield cytoplasmic fragment that binds to & activates members of the CSL family of transcription factors[3]
More general terms
More specific terms
- notch homolog 2 N-terminal-like protein (NOTCH2NL N2N)
- notch homolog 2 N-terminal-like protein B (NOTCH2NLB)
- notch homolog 2 N-terminal-like protein C (NOTCH2NLC)
- notch homolog 2 N-terminal-like protein R; NOTCH2NL-related (NOTCH2NLR)
- notch-1 (Drosophila) homolog protein; translocation-associated notch homolog (NOTCH1, TAN1)
- notch-2 (Drosophila) homolog protein (NOTCH2)
- notch-3 (Drosophila) homolog protein (NOTCH3)
- notch-4 (Drosophila) homolog protein (NOTCH4, INT3)
References
- ↑ OMIM https://mirror.omim.org/entry/[190198 600275 600276]
- ↑ 2.0 2.1 Kamal A, Almenar-Queralt A, LeBlanc JF, Roberts EA, Goldstein LS. Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP. Nature. 2001 Dec 6;414(6864):643-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11740561
- ↑ 3.0 3.1 Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev. 2001 Apr;81(2):741-66. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11274343