sirtuin 1; NAD-dependent deacetylase sirtuin 1; silent mating type information regulation 2 homolog 1 (SIRT1)

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Function

NAD+ + acetylprotein
     <-->
nicotinamide + O-acetyl-ADP-ribose + protein

Cofactor: binds 1 Zn+2 per subunit

Inhibition:

Activated by: (see SIRT1 activator)

Structure

  • belongs to the sirtuin family
  • contains 1 deacetylase sirtuin-type domain

Compartment

Expression

Polymorphism

Comparative biology

More general terms

Additional terms

Component of

References

  1. OMIM https://mirror.omim.org/entry/604479 UniProt http://www.uniprot.org/uniprot/Q96EB6.html
  2. Luo et al. Cell 107:137-148, 2001
  3. Vaziri et al. Cell 107:149-159, 2001
  4. 4.0 4.1 Brunet A et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 2004, 303:2011-2015 PMID: https://www.ncbi.nlm.nih.gov/pubmed/14976264
  5. 5.0 5.1 Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, Howitz KT, Gorospe M, de Cabo R, Sinclair DA. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science. 2004 Jul 16;305(5682):390-2. Epub 2004 Jun 17. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15205477 Wolf G Calorie restriction increases life span: a molecular mechanism. Nutr Rev 2006, 64:89 PMID: https://www.ncbi.nlm.nih.gov/pubmed/16536186
  6. 6.0 6.1 Qin W, Yang T, Ho L, Zhao Z, Wang J, Chen L, Zhao W, Thiyagarajan M, MacGrogan D, Rodgers JT, Puigserver P, Sadoshima J, Deng H, Pedrini S, Gandy S, Sauve AA, Pasinetti GM. Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. J Biol Chem. 2006 Aug 4;281(31):21745-54. Epub 2006 Jun 2. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16751189
  7. 7.0 7.1 Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, Bemis JE, Xie R, Disch JS, Ng PY, Nunes JJ, Lynch AV, Yang H, Galonek H, Israelian K, Choy W, Iffland A, Lavu S, Medvedik O, Sinclair DA, Olefsky JM, Jirousek MR, Elliott PJ, Westphal CH. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007 Nov 29;450(7170):712-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/18046409
  8. 8.0 8.1 Morimoto R, Northwestern University Proceedings of the 38th Annual Meeting of the American Aging Association: Integrative Biology: Hormones, Signaling, and Aging. May 29-June 1, 2009, Scottsdale, AZ
  9. 9.0 9.1 Donmez G et al. SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10. Cell 2010 Jul 23; 142:320 PMID: https://www.ncbi.nlm.nih.gov/pubmed/20655472
    Wolfe MS and Selkoe DJ. Giving Alzheimer's the old one-two. Cell 2010 Jul 23; 142:194 PMID: https://www.ncbi.nlm.nih.gov/pubmed/20655461
  10. 10.0 10.1 10.2 Yamakuchi M MicroRNA Regulation of SIRT1. Front Physiol. 2012;3:68. Epub 2012 Mar 30. PMID: https://www.ncbi.nlm.nih.gov/pubmed/22479251
  11. 11.0 11.1 Satoh A, Brace CS, Rensing N et al Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH. Cell Metab. 2013 Sep 3;18(3):416-30 PMID: https://www.ncbi.nlm.nih.gov/pubmed/24011076

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