APP alpha-secretase
Jump to navigation
Jump to search
Function
- may be one of several proteases cleaving the amyloid precursor protein (APP) within the region of the molecule giving rise to the A4 amyloid peptide (A-beta), thus precluding formation of A-beta
- specifically it cleaves between Lys16 & Leu17 of A-beta in the exoplasmic region of APP (see membrane domain region of APP)
- APP-alpha secretase cleaves both plasma membrane inserted APP & secretory vesicle-associated APP[3]
- proteases with alleged APP alpha secretase activity include:
- activity may be dimimished by cholesterol or cholesterol esters [2]
- it has been proposed that acetylcholine receptor or muscarinic receptor stimulation may enhance APP alpha-secretase activity.[1]
More general terms
More specific terms
- A disintegrin & metalloproteinase domain 10; Kuzbanian protein homolog; mammalian disintegrin-metalloprotease; CDw156; CD156c (ADAM10, KUZ, MADM)
- cathepsin-B (APP alpha-secretase)
- CD156b, A disintegrin & metalloproteinase domain 17; TNF-alpha-converting enzyme; TNF-alpha convertase; snake venom-like protease; CD156b (ADAM17, CSVP, TACE)
Additional terms
- A4 amyloid peptide; beta-peptide
- amyloid precursor protein; A4/beta amyloid precursor protein (APP)
- APP secretase
References
- ↑ 1.0 1.1 Cole G for Lee V. In: Intensive Course in Geriatric Medicine & Board Review, Marina Del Ray, CA, Sept 12-15, 2001 Mesulam M. The cholinergic lesion of Alzheimer's disease: pivotal factor or side show? Learn Mem. 2004 Jan-Feb;11(1):43-9. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/14747516
- ↑ 2.0 2.1 Marx J. Science 294:508, 2001
- ↑ 3.0 3.1 Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev. 2001 Apr;81(2):741-66. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11274343