A disintegrin & metalloproteinase domain 10; Kuzbanian protein homolog; mammalian disintegrin-metalloprotease; CDw156; CD156c (ADAM10, KUZ, MADM)

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Function

Cofactor: binds 1 Zn+2 (putative)

Structure

Compartment

Expression

Pathology

More general terms

References

  1. OMIM https://mirror.omim.org/entry/602192
  2. Yong VW et al Metalloproteinases in biology and pathology of the nervous system. Nat Rev Neurosci. 2001 Jul;2(7):502-11. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11433375
  3. 3.0 3.1 Marx J. Science 294:508, 2001
  4. UniProt http://www.uniprot.org/uniprot/O14672.html
  5. 5.0 5.1 Donmez G et al. SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10. Cell 2010 Jul 23; 142:320 PMID: https://www.ncbi.nlm.nih.gov/pubmed/20655472
    Wolfe MS and Selkoe DJ. Giving Alzheimer's the old one-two. Cell 2010 Jul 23; 142:194 PMID: https://www.ncbi.nlm.nih.gov/pubmed/20655461
  6. 6.0 6.1 Gul C, Kilic S, Sehitoglu MH. The importance of ADAM10 and ADAM17 metalloproteinases in the pathogenesis of psoriasis. Clin Exp Dermatol. 2022. April 26 PMID: https://www.ncbi.nlm.nih.gov/pubmed/35474465

Database