metalloproteinase inhibitor 2; Tissue inhibitor of metalloproteinases 2; TIMP-2; CSC-21K (TIMP2)
Jump to navigation
Jump to search
Function
- complexes with metalloproteinases (such as collagenases) & irreversibly inactivates them
- known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 & MMP-19
- activity of TIMP2 is dependent on the presence of disulfide bonds
Structure
- belongs to the protease inhibitor I35 (TIMP) family
- contains 1 NTR domain
- shows conservation of sequence with TIMP-1 including positions of 12 Cys
Compartment
Comparative biology
- TIMP2 derived from human umbilical cord plasma appears in the brain after systemic administration & enhances synaptic plasticity & hippocampal-dependent cognition in aged mice[5]
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P16035.html
- ↑ Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/TIMP2ID42572ch17q25.html
- ↑ Stetler-Stevenson WG et al TIMP-2: identification and characterization of a new member of the metalloproteinase inhibitor family. Marix Suppl 1:299 1992 PMID: https://www.ncbi.nlm.nih.gov/pubmed/1480041
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7077
- ↑ 5.0 5.1 Castellano JM, Mosher KI, Abbey RJ et al Human umbilical cord plasma proteins revitalize hippocampal function in aged mice. Nature. Apri 19, 2017 PMID: https://www.ncbi.nlm.nih.gov/pubmed/28424512 https://www.nature.com/nature/journal/vaop/ncurrent/full/nature22067.html