matrix metalloproteinase-2 (matrixin-2, TBE-1, 72 kD gelatinase, gelatinase A, MMP2, CLG4A)
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Function
- substrates:
- gelatin type 1
- collagen-4, collagen-5, collagen-7, collagen-10
- TGF-beta
- fibroblast growth factor receptor 1
- KiSS1 at a Gly-|-Leu bond
- specifically cleaves type IV collagen (basement membrane).
- ligand for integrin alpha-V/beta-3
- inhibited by histatin-3 1/24 (histatin-5)
- the propeptide is processed by MMP14 (MT-MMP1) & MMP16 (MT-MMP3)
- cleaves the collagen-like sequence Pro-Gln-gly-|-Ile-Ala-gly-Gln
Structure
- conserved Cys present in the cysteine-switch motif binds the catalytic Zn+2, thus inhibiting the enzyme; dissociation of the cysteine from the Zn+2 upon the activation-peptide release activates the enzyme
- belongs to the peptidase M10A family
- contains 3 fibronectin type-II domains
- contains 4 hemopexin-like domains
Expression
produced by normal skin fibroblasts
Pathology
- metastatic potential of transformed cells correlates with collagenase-4 activity
- defects in MMP2 are the cause of
Laboratory
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P08253.html
- ↑ Chang C, Werb Z. The many faces of metalloproteases: cell growth, invasion, angiogenesis and metastasis. Trends Cell Biol. 2001 Nov;11(11):S37-43. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11684441
- ↑ Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/MMP2ID41396ch16q13.html
Database
- UniProt: http://www.uniprot.org/uniprot/P08253.html
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4313
- OMIM: https://mirror.omim.org/entry/120360
- OMIM: https://mirror.omim.org/entry/277950
- OMIM: https://mirror.omim.org/entry/605156
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4313