collagen type-4
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Function
- the most important basement membrane collagen
- component of the filtration system in capillaries & the glomeruli of renal nephrons
- receptor is integrin alpha-1/beta-1
Compartment
Expression
- capillaries
- kidney
- lens of eye
Pathology
- defects associated with Alport syndrome
- role in pathogenesis of psoriasis[2]
More general terms
References
- ↑ Molecular Cell Biology (2nd ed) Darnell J; Lodish H & Baltimore D (eds), Scientific American Books, WH Freeman, NY 1990, pg 920
- ↑ 2.0 2.1 Conrad C, Boyman O, Tonel G, Tun-Kyi A, Laggner U, de Fougerolles A, Kotelianski V, Gardner H, Nestle FO. alpha(1)beta(1) integrin is crucial for accumulation of epidermal T cells and the development of psoriasis. Nat Med. 2007 Jul;13(7):836-42. Epub 2007 Jul 1. PMID: https://www.ncbi.nlm.nih.gov/pubmed/17603494
- ↑ Wikipedia, collagen entry http://en.wikipedia.org/wiki/collagen