very late antigen 1 (VLA-1), a laminin receptor
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Function
- receptor for laminin & collagen
- receptor for collagen-4 (basement membrane)
- recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen
Subunits
integrin alpha-1, integrin beta-1
Compartment
membrane
Expression
expressed in T-cells
Pathology
- role for epidermal T-cell integrin alpha-1/beta-1 & basement membrane collagen-4 in pathophysiology of psoriasis
More general terms
Additional terms
- fibronectin; FN; cold-insoluble globulin; CIG; contains: anastellin; Ugl-Y1; Ugl-Y2; Ugl-Y3 (FN1, FN)
- laminin
References
- ↑ Molecular Cell Biology (2nd ed) Darnell J; Lodish H & Baltimore D (eds), Scientific American Books, WH Freeman, NY 1990, pg 921
- ↑ UniProt http://www.uniprot.org/uniprot/P56199.html
- ↑ Conrad C, Boyman O, Tonel G, Tun-Kyi A, Laggner U, de Fougerolles A, Kotelianski V, Gardner H, Nestle FO. alpha(1)beta(1) integrin is crucial for accumulation of epidermal T cells and the development of psoriasis. Nat Med. 2007 Jul;13(7):836-42. Epub 2007 Jul 1. PMID: https://www.ncbi.nlm.nih.gov/pubmed/17603494