CD49a; integrin alpha-1; CD49 antigen-like family member A; laminin & collagen receptor; VLA-1 (ITGA1)

Function

• heterodimer with integrin beta-1 (integrin alpha-1/beta-1)
• recognizes proline-hydroxylated sequence G-F-P-G-E-R in collagen
• interacts with RAB21

Structure

• integrin I-domain (insert) is a VWFA domain
• integrins with I-domains do not undergo protease cleavage
• belongs to the integrin alpha chain family
• contains 7 FG-GAP repeats
• contains 1 VWFA domain

Compartment

membrane

Expression

• activated T cells & B cells
• monocytes

More general terms

• integrin-alpha
• CD antigen
• human longevity protein

Additional terms

• integrin

Component of

• very late antigen 1 (VLA-1), a laminin receptor

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3672
• OMIM: https://mirror.omim.org/entry/192968
• UniProt: http://www.uniprot.org/uniprot/P56199.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3672