integrin

Function

• cell surface receptors
• interact with the extracellular matrix
• role in attachment to other cells
• mediate intracellular signals
• role in cell shape, mobility, cell cycle
• bidirectional signalling
  • extracellular to intracellular signalling
  • intracellular to extracellular signalling

Structure

• composed of alpha & beta subunits selected from 16 alpha & 8 beta subunits that heterodimerize to produce more than 20 different receptors
• the short cytoplasmic domains of the alpha & beta subunits do not have intrinsic enzyme activity, but appear to function by nucleating large complexes of cytoskeletal proteins & cytoskeletal-associated protein kinases
• integrin beta-4 is the exception, with a cytoplasmic domain in excess of 1000 residues
• integrin-alpha(s) contain highly divergent amino acid sequences, whereas the integrin-beta subunits show partial sequence conservation
• the integrin-beta(s) target integrins to focal adhesions in a ligand-independent manner, whereas the integrin-alpha(s) regulate the specificity of ligand-dependent interactions

More general terms

• immunoglobulin superfamily protein
• adhesion receptor
• multisubunit protein

More specific terms

• CD49 or Very Late Antigen (VLA)
• glycoprotein IIB/IIIA
• integrin alpha-10/beta-1
• integrin alpha-11/beta-1
• integrin alpha-2b/beta-3
• integrin alpha-4/beta-7
• integrin alpha-6/beta-4
• integrin alpha-7/beta-1
• integrin alpha-8/beta-1
• integrin alpha-9/beta-1
• integrin alpha-D/beta-2 (CD11d/CD18)
• integrin alpha-E/beta-7
• integrin alpha-M/beta-2 (CD11b/CD18, MAC1)
• integrin alpha-V/beta-3
• integrin alpha-V/beta-5
• integrin alpha-V/beta-6
• integrin alpha-V/beta-8
• integrin alpha-X/beta-2 (CD11c/CD18)
• lymphocyte function-associated antigen-1 (LFA-1, leukocyte adhesion protein LFA-1, integrin alpha-L/beta-2, CD11a/CD18)
• vitronectin receptor