CD104 (integrin-beta 4, GP150, ITGB4)

Function

• associates with integrin alpha 6 (integrin alpha-6/beta-4)
• signalling through the integrin beta-4 cytoplasmic domain may induce expression of p21WAF1/Cip1

Structure

• the fibronectin type-III-like domains bind BPAG1 & plectin & probably also recruit BP230
• belongs to the integrin beta chain family
• contains 1 calx-beta domain
• contains 4 fibronectin F3 modules
• contains 1 VWFA domain

Compartment

membrane

Expression

• thymocytes, epithelial cells
• isoform beta-4D is also expressed in colon & placenta
• isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen & stomach

Pathology

• mutations associated with
• epidermolysis bullosa letalis with pyloric atresia (junctional epidermolysis bullosa with pyloric atresia or aplasia cutis congenita with gastrointestinal atresia)
• generalized atrophic benign epidermolysis bullosa

More general terms

• integrin-beta
• glycoprotein
• CD antigen

Component of

• integrin alpha-6/beta-4

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3690
• OMIM: https://mirror.omim.org/entry/173470
• OMIM: https://mirror.omim.org/entry/273800
• UniProt: http://www.uniprot.org/uniprot/P16144.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3691