cyclin-dependent kinase inhibitor 1; p21WAF1/CIP1; p21; CDK-interacting protein 1; melanoma differentiation-associated protein 6; MDA-6 (CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1)

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Function

Structure

belongs to the CDI family

Compartment

cytoplasm, nucleus

Expression

More general terms

Additional terms

References

  1. Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, Kastan MB, O'Connor PM, Fornace AJ Jr. Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. Science. 1994 Nov 25;266(5189):1376-80. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7973727
  2. Marx Science 266:1231 1994 [News & Views]
  3. Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell. 1993 Nov 19;75(4):805-16. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8242751
  4. el-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW, Vogelstein B. WAF1, a potential mediator of p53 tumor suppression. Cell. 1993 Nov 19;75(4):817-25. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8242752
  5. Hunter T. Cooperation between oncogenes. Cell. 1991 Jan 25;64(2):249-70. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1988147
  6. Noda A, Ning Y, Venable SF, Pereira-Smith OM, Smith JR. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp Cell Res. 1994 Mar;211(1):90-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8125163
  7. 7.0 7.1 Morgan DO. Principles of CDK regulation. Nature. 1995 Mar 9;374(6518):131-4. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7877684
  8. 8.0 8.1 Pan ZQ, Reardon JT, Li L, Flores-Rozas H, Legerski R, Sancar A, Hurwitz J. Inhibition of nucleotide excision repair by the cyclin- dependent kinase inhibitor p21. J Biol Chem. 1995 Sep 15;270(37):22008-16. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7665622
  9. 9.0 9.1 Cordon-Cardo C. Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia. Am J Pathol. 1995 Sep;147(3):545-60. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7677168
  10. 10.0 10.1 Shim J, Lee H, Park J, Kim H, Choi EJ. A non-enzymatic p21 protein inhibitor of stress-activated protein kinases. Nature. 1996 Jun 27;381(6585):804-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8657286
  11. 11.0 11.1 Seoane J et al Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage. Nature. 2002 Oct 17;419(6908):729-34. Epub 2002 Oct 2. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12384701
  12. Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1026
  13. UniProt http://www.uniprot.org/uniprot/P38936.html
  14. Atlas of genetics & cytogenetics in oncology & haematology http://atlasgeneticsoncology.org/genes/CDKN1AID139.html
  15. NIEHS-SNPs http://egp.gs.washington.edu/data/cdkn1a/

Database