zinc finger & BTB domain-containing protein 17; zinc finger protein 60; zinc finger protein 151; Myc-interacting zinc finger protein; Miz-1 (ZBTB17, MIZ1, ZNF151, ZNF60)

Function

• may function as a housekeeping DNA-binding protein that regulates the expression of specific genes
• binds to the promoters of adenovirus major late protein & cyclin D1 & activates transcription
• has potent growth arrest activity, probably through inhibition of cell cycle progression
• required for early embryonic development during gastrulation
• binds to the C-terminal helix-loop-helix motif of c-myc which inhibits ZBTB17 transactivation & growth arrest activities & renders it insoluble in the nucleus
• c-myc is recruited to the p21WAF1/Cip1 promoter by ZBTB17; this blocks p21WAF1/Cip1 induction by p53 & other activators; c-myc does not affect p53 binding but inhibits bound p53 from activating transcription
• interacts with HCFC1, MAGEA4 & TMPRSS11A

Structure

• belongs to the krueppel C2H2-type Zn+2-finger protein family
• contains 1 BTB/POZ domain
• contains 13 C2H2-type Zn+2 fingers

Compartment

nucleus

Alternative splicing

named isoforms=2

More general terms

• Zinc finger & BTB domain containing protein
• DNA-binding protein
• transcription factor (TF)
• C2H2 type zinc finger protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7709
• OMIM: https://mirror.omim.org/entry/604084
• UniProt: http://www.uniprot.org/uniprot/Q13105.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7709