transmembrane protease, serine 11A (epidermal type-2 transmembrane serine protease, airway trypsin-like protease 1, esophageal cancer-susceptibility gene 1 protein, TMPRSS11A, ECRG1, HATL1, HESP)

Function

• probable serine protease
• may play a role in cellular senescence
• overexpression inhibits cell growth & induces G1 cell cycle arrest
• may interact with ZBTB17

Structure

• belongs to the peptidase S1 family
• contains 1 peptidase S1 domain
• contains 1 SEA domain

Compartment

membrane (putative)

Alternative splicing

named isoforms=2

Expression

• expressed in esophagus, liver, colon & lung

Pathology

down-regulated in esophageal cancers

More general terms

• transmembrane serine protease

Database

• UniProt: http://www.uniprot.org/uniprot/Q6ZMR5.html