adenovirus
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Introduction
Serotype determines extent of disease: 52 serotypes
Epidemiology
- military outbreaks
Pathology
- fevers
- gastroenteritis: diarrhea
- respiratory tract infections
- etiology of common cold
- cough
- serotype 14 associated with pneumonia[2]
- pharyngitis
- bilateral conjunctivitis
- serotype 41 may be associated with acute hepatitis in children[5]
- adenovirus has oncogenic potential
- CXADR interacts with adenovirus subgroup A, C, D, E & F fiber proteins & acts as an adenovirus receptor
Laboratory
- adenovirus antigen
- direct immunofluorescence assay (DFA) (60% sensitivity)
- adenovirus+rotavirus Ag in stool
- adenovirus+rotavirus in stool
- adenovirus serology
- adenovirus nucleic acid
- adenovirus type in specimen
- adenovirus identified by culture
- see ARUP consult[3]
Differential diagnosis
- influenza: conjunctivitis unlikely
- respiratory syncytial virus: conjunctivitis unlikely
- Coxsackie virus: conjunctivitis & lower respiratory tract infection unlikely
- cytomegalovirus is associated with retinitis[7]
Management
- cidofovir is most often used in clinical practice
- poor bioavailability & associated nephrotoxicity
- brincidofovir
- not nephrotoxic, but associated with diarrhea
- contact precautions & droplet precautions for respiratory adenovirus infection[6]
More general terms
Additional terms
References
- ↑ Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995
- ↑ Jump up to: 2.0 2.1 Centers for Disease Control and Prevention (CDC). Acute respiratory disease associated with adenovirus serotype 14 - four states, 2006-2007 MMWR Morb Mort Wkly Rep 2007, 56:1181 PMID: https://www.ncbi.nlm.nih.gov/pubmed/18004235
Louie JK et al, Severe pneumonia due to adenovirus serotype 14: A new respiratory threat? Clin Infect Dis 2008, 46:421 PMID: https://www.ncbi.nlm.nih.gov/pubmed/18173356 - ↑ Jump up to: 3.0 3.1 ARUP Consult: Adenovirus The Physician's Guide to Laboratory Test Selection & Interpretation https://www.arupconsult.com/browse-all-topics
- ↑ Hibbert KA, Shepard JAO, Lane RJ, Azar MM. Case 1-2018 - A 39-Year-Old Woman with Rapidly Progressive Respiratory Failure. N Engl J Med 2018; 378:182-190. January 11, 2018 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/29320657 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMcpc1712222
- ↑ Jump up to: 5.0 5.1 Phend C Unexplained Acute Hepatitis in Children: More Evidence for Adenovirus 41. Two studies point to a suspiciously high prevalence. MedPage Today July 13, 2022 https://www.medpagetoday.com/infectiousdisease/hepatitis/99707
Gutierrez Sanchez LH et al A Case Series of Children with Acute Hepatitis and Human Adenovirus Infection. N Engl J Med. 2022. July 13 PMID: https://www.ncbi.nlm.nih.gov/pubmed/35830653 https://www.nejm.org/doi/full/10.1056/NEJMoa2206294
Kelgeri C et al Clinical spectrum of children with acute hepatitis of unknown cause. N Engl J Med. 2022. July 13 PMID: https://www.ncbi.nlm.nih.gov/pubmed/35830627 https://www.nejm.org/doi/full/10.1056/NEJMoa2206704 - ↑ Jump up to: 6.0 6.1 Medical Knowledge Self Assessment Program (MKSAP) 19 Board Basics. An Enhancement to MKSAP19. American College of Physicians, Philadelphia 2022
- ↑ Jump up to: 7.0 7.1 NEJM Knowledge+ Lynch JP 3rd, Fishbein M, Echavarria M.
Adenovirus. Semin Respir Crit Care Med. 2011 Aug;32(4):494-511. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21858752 Review. - ↑ Lynch JP 3rd, Kajon AE. Adenovirus: Epidemiology, Global Spread of Novel Types, and Approach to Treatment. Semin Respir Crit Care Med. 2021 Dec;42(6):800-821. PMID: https://www.ncbi.nlm.nih.gov/pubmed/34918322