Coxsackievirus & adenovirus receptor; CAR; hCAR; CVB3-binding protein; Coxsackievirus B-adenovirus receptor; HCVADR (CXADR CAR)

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Function

component of the epithelial apical junction complex
homophilic cell adhesion molecule (putative)
recruits MPDZ to intercellular contact sites
probably involved in transepithelial migration of neutrophils through adhesive interactions with AMICA1/JAML located in the plasma membrane of neutrophils
palmitoylated on Cys-259 &/or Cys-260; required for proper localization to the plasma membrane
monomer; probably homodimer formed by 2 molecules on adjacent cells
interacts with LNX, MPDZ, BAIAP1, DLG4, PRKCABP, TJP1 & CTNNB1
secreted isoform 3, isoform 4 & isoform 5 can interact with the extracellular domain of the receptor
interacts with DNAJC7
probably part of a complex containing CXADR, HSP90AA1 & DNAJC7 (putative)

N-glycosylated (putative)
the Ig-like C2-type 1 domain probably mediates homodimerization & interaction with JAML
the PDZ-binding motif mediates interaction with MPDZ & BAIAP1
contains 2 Ig-like C2-type domains

expressed in pancreas, brain, heart, small intestine, testis, prostate
lower expession in liver & lung
isoform 5 is ubiquitously expressed
isoform 3 is expressed in heart, lung & pancreas
in skeletal muscle, isoform 1 is found at the neuromuscular junction & isoform 2 is found in blood vessels
in cardiac muscle, isoform 1 & isoform 2 are found at intercalated disks
in heart
- expressed in subendothelial layers of the vessel wall
- not found in the luminal endothelial surface
- expression is elevated in hearts with dilated cardiomyopathy

interacts with adenovirus subgroup A, C, D, E & F fiber proteins as well as coxsackievirus B1, B2, B3, B4, B5 & B6 capsid proteins & acts as a receptor for these viruses