multiple PDZ domain protein (multi PDZ domain protein 1, multi-PDZ-domain protein 1, MPDZ, MUPP1)

Function

• interacts with HTR2C & provokes its clustering at the cell surface (putative)
• component of the NMDAR signaling complex
• interacts with CLDN5, DLG4, GRIN1, F11R/JAM, CLDN1, NG2, CRB1, MPP4, MPP5
• interacts with HTR2A, HTR2B, HTR2C, PLEKHA1/TAPP1, PLEKHA2/TAPP2, CXADR, SYNGAP1, CAMK2A & CAMK2B
• PDZ domain 1 binds NG2 PDZ domain 9 binds F11R PDZ domain 10 binds the C-terminus of CLDN1 & KIT & C-terminal PDZ-binding motif of HTR2C PDZ domain 13 binds CXADR PDZ domain 2 binds CAMK2A & CAMK2B PDZ domains 10 & 13 bind PLEKHA1 & PLEKHA2 PDZ domain 13 binds SYNGAP1

Structure

• contains 1 L27 domain
• contains 13 PDZ domain (DHR domains)

Compartment

• cell membrane, cytoplasmic side
• colocalizes with HTR2C on the apical membrane of epithelial choroid plexus cells
• enriched in postsynaptic densities (PSD)
• localized to punctae on dendrites of hippocampal neurons
• colocalizes with synaptic marker DLG4
• localized in Schmidt-Lanterman incisures of myelinating Schwann cells
• in the retina, localizes to sub-apical region adjacent to adherens junction complex at the outer limiting membrane
• enriched at tight junctions of epithelial cells (CXADR-dependent)

Alternative splicing

named isoforms=3

Expression

• expressed in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas

Pathology

• interacts with the adenovirus type 9 E4-ORF1 protein
• PDZ domains 7 & 10 bind the Ad9 E4-ORF1 oncoprotein

More general terms

• other protein

Component of

• NMDAR signaling complex

Database

• OMIM: https://mirror.omim.org/entry/603785
• UniProt: http://www.uniprot.org/uniprot/O75970.html